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A phenotypic screening platform utilising human spermatozoa identifies compounds with contraceptive activity

There is an urgent need to develop new methods for male contraception, however a major barrier to drug discovery has been the lack of validated targets and the absence of an effective high-throughput phenotypic screening system. To address this deficit, we developed a fully-automated robotic screeni...

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Detalles Bibliográficos
Autores principales: Gruber, Franz S, Johnston, Zoe C, Barratt, Christopher LR, Andrews, Paul D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046468/
https://www.ncbi.nlm.nih.gov/pubmed/31987071
http://dx.doi.org/10.7554/eLife.51739