Macrophage-Derived Exosomal Mir-155 Regulating Cardiomyocyte Pyroptosis and Hypertrophy in Uremic Cardiomyopathy

miR-155 was synthesized and loaded into exosomes in increased infiltration of macrophages in a uremic heart. The released exosomal fusion with the plasma membrane leads to the release of miR-155 into the cytosol and translational repression of forkhead transcription factors of the O class (FoxO3a) i...

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Detalles Bibliográficos
Autores principales: Wang, Bin, Wang, Ze-Mu, Ji, Jia-Ling, Gan, Weihua, Zhang, Aiqing, Shi, Hao-Jie, Wang, Hao, Lv, Linli, Li, Zuolin, Tang, Taotao, Du, Jie, Wang, Xiaonan H., Liu, Bi-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046511/
https://www.ncbi.nlm.nih.gov/pubmed/32140622
http://dx.doi.org/10.1016/j.jacbts.2019.10.011
Descripción
Sumario:miR-155 was synthesized and loaded into exosomes in increased infiltration of macrophages in a uremic heart. The released exosomal fusion with the plasma membrane leads to the release of miR-155 into the cytosol and translational repression of forkhead transcription factors of the O class (FoxO3a) in cardiomyocytes. Finally, macrophage-derived miR-155–containing exosomes promoted cardiomyocyte pyroptosis and uremic cardiomyopathy changes (cardiac hypertrophy and fibrosis) by directly targeting FoxO3a in uremic mice.

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