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Macrophage-Derived Exosomal Mir-155 Regulating Cardiomyocyte Pyroptosis and Hypertrophy in Uremic Cardiomyopathy
miR-155 was synthesized and loaded into exosomes in increased infiltration of macrophages in a uremic heart. The released exosomal fusion with the plasma membrane leads to the release of miR-155 into the cytosol and translational repression of forkhead transcription factors of the O class (FoxO3a) i...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046511/ https://www.ncbi.nlm.nih.gov/pubmed/32140622 http://dx.doi.org/10.1016/j.jacbts.2019.10.011 |
| _version_ | 1783501960334278656 |
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| author | Wang, Bin Wang, Ze-Mu Ji, Jia-Ling Gan, Weihua Zhang, Aiqing Shi, Hao-Jie Wang, Hao Lv, Linli Li, Zuolin Tang, Taotao Du, Jie Wang, Xiaonan H. Liu, Bi-Cheng |
| author_facet | Wang, Bin Wang, Ze-Mu Ji, Jia-Ling Gan, Weihua Zhang, Aiqing Shi, Hao-Jie Wang, Hao Lv, Linli Li, Zuolin Tang, Taotao Du, Jie Wang, Xiaonan H. Liu, Bi-Cheng |
| author_sort | Wang, Bin |
| collection | PubMed |
| description | miR-155 was synthesized and loaded into exosomes in increased infiltration of macrophages in a uremic heart. The released exosomal fusion with the plasma membrane leads to the release of miR-155 into the cytosol and translational repression of forkhead transcription factors of the O class (FoxO3a) in cardiomyocytes. Finally, macrophage-derived miR-155–containing exosomes promoted cardiomyocyte pyroptosis and uremic cardiomyopathy changes (cardiac hypertrophy and fibrosis) by directly targeting FoxO3a in uremic mice. |
| format | Online Article Text |
| id | pubmed-7046511 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-70465112020-03-05 Macrophage-Derived Exosomal Mir-155 Regulating Cardiomyocyte Pyroptosis and Hypertrophy in Uremic Cardiomyopathy Wang, Bin Wang, Ze-Mu Ji, Jia-Ling Gan, Weihua Zhang, Aiqing Shi, Hao-Jie Wang, Hao Lv, Linli Li, Zuolin Tang, Taotao Du, Jie Wang, Xiaonan H. Liu, Bi-Cheng JACC Basic Transl Sci PRECLINICAL RESEARCH miR-155 was synthesized and loaded into exosomes in increased infiltration of macrophages in a uremic heart. The released exosomal fusion with the plasma membrane leads to the release of miR-155 into the cytosol and translational repression of forkhead transcription factors of the O class (FoxO3a) in cardiomyocytes. Finally, macrophage-derived miR-155–containing exosomes promoted cardiomyocyte pyroptosis and uremic cardiomyopathy changes (cardiac hypertrophy and fibrosis) by directly targeting FoxO3a in uremic mice. Elsevier 2020-01-15 /pmc/articles/PMC7046511/ /pubmed/32140622 http://dx.doi.org/10.1016/j.jacbts.2019.10.011 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | PRECLINICAL RESEARCH Wang, Bin Wang, Ze-Mu Ji, Jia-Ling Gan, Weihua Zhang, Aiqing Shi, Hao-Jie Wang, Hao Lv, Linli Li, Zuolin Tang, Taotao Du, Jie Wang, Xiaonan H. Liu, Bi-Cheng Macrophage-Derived Exosomal Mir-155 Regulating Cardiomyocyte Pyroptosis and Hypertrophy in Uremic Cardiomyopathy |
| title | Macrophage-Derived Exosomal Mir-155 Regulating Cardiomyocyte Pyroptosis and Hypertrophy in Uremic Cardiomyopathy |
| title_full | Macrophage-Derived Exosomal Mir-155 Regulating Cardiomyocyte Pyroptosis and Hypertrophy in Uremic Cardiomyopathy |
| title_fullStr | Macrophage-Derived Exosomal Mir-155 Regulating Cardiomyocyte Pyroptosis and Hypertrophy in Uremic Cardiomyopathy |
| title_full_unstemmed | Macrophage-Derived Exosomal Mir-155 Regulating Cardiomyocyte Pyroptosis and Hypertrophy in Uremic Cardiomyopathy |
| title_short | Macrophage-Derived Exosomal Mir-155 Regulating Cardiomyocyte Pyroptosis and Hypertrophy in Uremic Cardiomyopathy |
| title_sort | macrophage-derived exosomal mir-155 regulating cardiomyocyte pyroptosis and hypertrophy in uremic cardiomyopathy |
| topic | PRECLINICAL RESEARCH |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046511/ https://www.ncbi.nlm.nih.gov/pubmed/32140622 http://dx.doi.org/10.1016/j.jacbts.2019.10.011 |
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