Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation

Increasing left atrial (LA) size predicts outcomes in patients with isolated mitral regurgitation (MR). Chymase is plentiful in the human heart and affects extracellular matrix remodeling. Chymase activation correlates to LA fibrosis, LA enlargement, and a decreased total LA emptying fraction in add...

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Detalles Bibliográficos
Autores principales: Butts, Brittany, Ahmed, Mustafa I., Bajaj, Navkaranbir S., Cox Powell, Pamela, Pat, Betty, Litovsky, Silvio, Gupta, Himanshu, Lloyd, Steven G., Denney, Thomas S., Zhang, Xiaoxia, Aban, Inmaculada, Sadayappan, Sakthivel, McNamara, James W., Watson, Michael J., Ferrario, Carlos M., Collawn, James F., Lewis, Clifton, Davies, James E., Dell’Italia, Louis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
CLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046515/
https://www.ncbi.nlm.nih.gov/pubmed/32140620
http://dx.doi.org/10.1016/j.jacbts.2019.11.006
Descripción
Sumario:Increasing left atrial (LA) size predicts outcomes in patients with isolated mitral regurgitation (MR). Chymase is plentiful in the human heart and affects extracellular matrix remodeling. Chymase activation correlates to LA fibrosis, LA enlargement, and a decreased total LA emptying fraction in addition to having a potential intracellular role in mediating myofibrillar breakdown in LA myocytes. Because of the unreliability of the left ventricular ejection fraction in predicting outcomes in MR, LA size and the total LA emptying fraction may be more suitable indicators for timing of surgical intervention.

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