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Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation
Increasing left atrial (LA) size predicts outcomes in patients with isolated mitral regurgitation (MR). Chymase is plentiful in the human heart and affects extracellular matrix remodeling. Chymase activation correlates to LA fibrosis, LA enlargement, and a decreased total LA emptying fraction in add...
| Autores principales: | , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046515/ https://www.ncbi.nlm.nih.gov/pubmed/32140620 http://dx.doi.org/10.1016/j.jacbts.2019.11.006 |
| _version_ | 1783501961267511296 |
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| author | Butts, Brittany Ahmed, Mustafa I. Bajaj, Navkaranbir S. Cox Powell, Pamela Pat, Betty Litovsky, Silvio Gupta, Himanshu Lloyd, Steven G. Denney, Thomas S. Zhang, Xiaoxia Aban, Inmaculada Sadayappan, Sakthivel McNamara, James W. Watson, Michael J. Ferrario, Carlos M. Collawn, James F. Lewis, Clifton Davies, James E. Dell’Italia, Louis J. |
| author_facet | Butts, Brittany Ahmed, Mustafa I. Bajaj, Navkaranbir S. Cox Powell, Pamela Pat, Betty Litovsky, Silvio Gupta, Himanshu Lloyd, Steven G. Denney, Thomas S. Zhang, Xiaoxia Aban, Inmaculada Sadayappan, Sakthivel McNamara, James W. Watson, Michael J. Ferrario, Carlos M. Collawn, James F. Lewis, Clifton Davies, James E. Dell’Italia, Louis J. |
| author_sort | Butts, Brittany |
| collection | PubMed |
| description | Increasing left atrial (LA) size predicts outcomes in patients with isolated mitral regurgitation (MR). Chymase is plentiful in the human heart and affects extracellular matrix remodeling. Chymase activation correlates to LA fibrosis, LA enlargement, and a decreased total LA emptying fraction in addition to having a potential intracellular role in mediating myofibrillar breakdown in LA myocytes. Because of the unreliability of the left ventricular ejection fraction in predicting outcomes in MR, LA size and the total LA emptying fraction may be more suitable indicators for timing of surgical intervention. |
| format | Online Article Text |
| id | pubmed-7046515 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-70465152020-03-05 Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation Butts, Brittany Ahmed, Mustafa I. Bajaj, Navkaranbir S. Cox Powell, Pamela Pat, Betty Litovsky, Silvio Gupta, Himanshu Lloyd, Steven G. Denney, Thomas S. Zhang, Xiaoxia Aban, Inmaculada Sadayappan, Sakthivel McNamara, James W. Watson, Michael J. Ferrario, Carlos M. Collawn, James F. Lewis, Clifton Davies, James E. Dell’Italia, Louis J. JACC Basic Transl Sci CLINICAL RESEARCH Increasing left atrial (LA) size predicts outcomes in patients with isolated mitral regurgitation (MR). Chymase is plentiful in the human heart and affects extracellular matrix remodeling. Chymase activation correlates to LA fibrosis, LA enlargement, and a decreased total LA emptying fraction in addition to having a potential intracellular role in mediating myofibrillar breakdown in LA myocytes. Because of the unreliability of the left ventricular ejection fraction in predicting outcomes in MR, LA size and the total LA emptying fraction may be more suitable indicators for timing of surgical intervention. Elsevier 2020-01-22 /pmc/articles/PMC7046515/ /pubmed/32140620 http://dx.doi.org/10.1016/j.jacbts.2019.11.006 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | CLINICAL RESEARCH Butts, Brittany Ahmed, Mustafa I. Bajaj, Navkaranbir S. Cox Powell, Pamela Pat, Betty Litovsky, Silvio Gupta, Himanshu Lloyd, Steven G. Denney, Thomas S. Zhang, Xiaoxia Aban, Inmaculada Sadayappan, Sakthivel McNamara, James W. Watson, Michael J. Ferrario, Carlos M. Collawn, James F. Lewis, Clifton Davies, James E. Dell’Italia, Louis J. Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation |
| title | Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation |
| title_full | Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation |
| title_fullStr | Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation |
| title_full_unstemmed | Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation |
| title_short | Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation |
| title_sort | reduced left atrial emptying fraction and chymase activation in pathophysiology of primary mitral regurgitation |
| topic | CLINICAL RESEARCH |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046515/ https://www.ncbi.nlm.nih.gov/pubmed/32140620 http://dx.doi.org/10.1016/j.jacbts.2019.11.006 |
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