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Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation

Increasing left atrial (LA) size predicts outcomes in patients with isolated mitral regurgitation (MR). Chymase is plentiful in the human heart and affects extracellular matrix remodeling. Chymase activation correlates to LA fibrosis, LA enlargement, and a decreased total LA emptying fraction in add...

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Detalles Bibliográficos
Autores principales:	Butts, Brittany, Ahmed, Mustafa I., Bajaj, Navkaranbir S., Cox Powell, Pamela, Pat, Betty, Litovsky, Silvio, Gupta, Himanshu, Lloyd, Steven G., Denney, Thomas S., Zhang, Xiaoxia, Aban, Inmaculada, Sadayappan, Sakthivel, McNamara, James W., Watson, Michael J., Ferrario, Carlos M., Collawn, James F., Lewis, Clifton, Davies, James E., Dell’Italia, Louis J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	CLINICAL RESEARCH
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046515/ https://www.ncbi.nlm.nih.gov/pubmed/32140620 http://dx.doi.org/10.1016/j.jacbts.2019.11.006

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