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Implementation of an active case management network to identify HIV‐positive infants and accelerate the initiation of antiretroviral therapy, Thailand 2015 to 2018

INTRODUCTION: Early initiation of antiretroviral therapy (ART) can reduce HIV‐related morbidity and mortality in HIV‐positive infants. We implemented an Active Case Management Network to promote early ART initiation Aiming for Cure (ACC) in August 2014. We describe ACC implementation, early infant d...

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Autores principales: Lolekha, Rangsima, Pavaputanon, Patcharaporn, Puthanakit, Thanyawee, Martin, Michael, Kosalaraksa, Pope, Petdachai, Witaya, Borkird, Thitiporn, Hansudewechakul, Rawiwan, Rojanawiwat, Archawin, Boonsuk, Sarawut, Samleerat, Tanawan, Ongwandee, Sumet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046526/
https://www.ncbi.nlm.nih.gov/pubmed/32107884
http://dx.doi.org/10.1002/jia2.25450
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author Lolekha, Rangsima
Pavaputanon, Patcharaporn
Puthanakit, Thanyawee
Martin, Michael
Kosalaraksa, Pope
Petdachai, Witaya
Borkird, Thitiporn
Hansudewechakul, Rawiwan
Rojanawiwat, Archawin
Boonsuk, Sarawut
Samleerat, Tanawan
Ongwandee, Sumet
author_facet Lolekha, Rangsima
Pavaputanon, Patcharaporn
Puthanakit, Thanyawee
Martin, Michael
Kosalaraksa, Pope
Petdachai, Witaya
Borkird, Thitiporn
Hansudewechakul, Rawiwan
Rojanawiwat, Archawin
Boonsuk, Sarawut
Samleerat, Tanawan
Ongwandee, Sumet
author_sort Lolekha, Rangsima
collection PubMed
description INTRODUCTION: Early initiation of antiretroviral therapy (ART) can reduce HIV‐related morbidity and mortality in HIV‐positive infants. We implemented an Active Case Management Network to promote early ART initiation Aiming for Cure (ACC) in August 2014. We describe ACC implementation, early infant diagnosis (EID) coverage and ART initiation during August 2014 to July 2018 compared with a national EID survey during October 2007 to September 2011 (pre‐ACC). METHODS: Thailand's 2014 HIV Treatment Guidelines recommend that HIV‐exposed infants have HIV polymerase chain reaction (PCR) testing at birth, one month and at two to four months. Testing is done at 14 national HIV PCR laboratories. When an HIV‐positive infant (HIV PCR+) is identified, PCR laboratory staff send the result to the hospital staff responsible for the infant's care and to the national laboratory case manager (CM). As part of ACC, the national laboratory CM alerts a regional CM who contacts the hospital staff caring for the infant to offer technical support with ART initiation and ART adherence. CMs enter clinical, demographic and laboratory data into the national ACC database. We analysed the ACC data from August 2014 to July 2018 to assess the ACC's impact on EID coverage, ART initiation and time‐to‐ART initiation. RESULTS: The uptake of EID increased from 64% (pre‐ACC) to >95% in 2018 (ACC). The number of HIV‐positive infants born declined from 429 cases (pre‐ACC) to 267 cases (ACC). Median age at the first‐positive PCR declined from 75 days (pre‐ACC) to 60 days (ACC); P < 0.001. Among 429 infants diagnosed before ACC was started, 241 (56%) received ART; during ACC, 235 (88%) of 267 HIV‐positive infants received ART. The median age at ART initiation declined from 282 days before ACC to 83 days during ACC (P < 0.001) and the median time from blood collection to ART initiation declined from 168 days before ACC to 23 days during ACC (P < 0.001). CONCLUSIONS: An innovative case management network (ACC) has been established in Thailand and results suggest that the network is promoting EID and early ART initiation. The ACC model, using case‐managed PCR notification and follow‐up, may speed ART initiation in other settings.
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spelling pubmed-70465262020-03-03 Implementation of an active case management network to identify HIV‐positive infants and accelerate the initiation of antiretroviral therapy, Thailand 2015 to 2018 Lolekha, Rangsima Pavaputanon, Patcharaporn Puthanakit, Thanyawee Martin, Michael Kosalaraksa, Pope Petdachai, Witaya Borkird, Thitiporn Hansudewechakul, Rawiwan Rojanawiwat, Archawin Boonsuk, Sarawut Samleerat, Tanawan Ongwandee, Sumet J Int AIDS Soc Research Articles INTRODUCTION: Early initiation of antiretroviral therapy (ART) can reduce HIV‐related morbidity and mortality in HIV‐positive infants. We implemented an Active Case Management Network to promote early ART initiation Aiming for Cure (ACC) in August 2014. We describe ACC implementation, early infant diagnosis (EID) coverage and ART initiation during August 2014 to July 2018 compared with a national EID survey during October 2007 to September 2011 (pre‐ACC). METHODS: Thailand's 2014 HIV Treatment Guidelines recommend that HIV‐exposed infants have HIV polymerase chain reaction (PCR) testing at birth, one month and at two to four months. Testing is done at 14 national HIV PCR laboratories. When an HIV‐positive infant (HIV PCR+) is identified, PCR laboratory staff send the result to the hospital staff responsible for the infant's care and to the national laboratory case manager (CM). As part of ACC, the national laboratory CM alerts a regional CM who contacts the hospital staff caring for the infant to offer technical support with ART initiation and ART adherence. CMs enter clinical, demographic and laboratory data into the national ACC database. We analysed the ACC data from August 2014 to July 2018 to assess the ACC's impact on EID coverage, ART initiation and time‐to‐ART initiation. RESULTS: The uptake of EID increased from 64% (pre‐ACC) to >95% in 2018 (ACC). The number of HIV‐positive infants born declined from 429 cases (pre‐ACC) to 267 cases (ACC). Median age at the first‐positive PCR declined from 75 days (pre‐ACC) to 60 days (ACC); P < 0.001. Among 429 infants diagnosed before ACC was started, 241 (56%) received ART; during ACC, 235 (88%) of 267 HIV‐positive infants received ART. The median age at ART initiation declined from 282 days before ACC to 83 days during ACC (P < 0.001) and the median time from blood collection to ART initiation declined from 168 days before ACC to 23 days during ACC (P < 0.001). CONCLUSIONS: An innovative case management network (ACC) has been established in Thailand and results suggest that the network is promoting EID and early ART initiation. The ACC model, using case‐managed PCR notification and follow‐up, may speed ART initiation in other settings. John Wiley and Sons Inc. 2020-02-27 /pmc/articles/PMC7046526/ /pubmed/32107884 http://dx.doi.org/10.1002/jia2.25450 Text en © 2020 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Lolekha, Rangsima
Pavaputanon, Patcharaporn
Puthanakit, Thanyawee
Martin, Michael
Kosalaraksa, Pope
Petdachai, Witaya
Borkird, Thitiporn
Hansudewechakul, Rawiwan
Rojanawiwat, Archawin
Boonsuk, Sarawut
Samleerat, Tanawan
Ongwandee, Sumet
Implementation of an active case management network to identify HIV‐positive infants and accelerate the initiation of antiretroviral therapy, Thailand 2015 to 2018
title Implementation of an active case management network to identify HIV‐positive infants and accelerate the initiation of antiretroviral therapy, Thailand 2015 to 2018
title_full Implementation of an active case management network to identify HIV‐positive infants and accelerate the initiation of antiretroviral therapy, Thailand 2015 to 2018
title_fullStr Implementation of an active case management network to identify HIV‐positive infants and accelerate the initiation of antiretroviral therapy, Thailand 2015 to 2018
title_full_unstemmed Implementation of an active case management network to identify HIV‐positive infants and accelerate the initiation of antiretroviral therapy, Thailand 2015 to 2018
title_short Implementation of an active case management network to identify HIV‐positive infants and accelerate the initiation of antiretroviral therapy, Thailand 2015 to 2018
title_sort implementation of an active case management network to identify hiv‐positive infants and accelerate the initiation of antiretroviral therapy, thailand 2015 to 2018
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046526/
https://www.ncbi.nlm.nih.gov/pubmed/32107884
http://dx.doi.org/10.1002/jia2.25450
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