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Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease

Huntington’s disease (HD) is caused by Huntingtin (Htt) gene mutation resulting in the loss of striatal GABAergic neurons and motor functional deficits. We report here an in vivo cell conversion technology to reprogram striatal astrocytes into GABAergic neurons in both R6/2 and YAC128 HD mouse model...

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Detalles Bibliográficos
Autores principales:	Wu, Zheng, Parry, Matthew, Hou, Xiao-Yi, Liu, Min-Hui, Wang, Hui, Cain, Rachel, Pei, Zi-Fei, Chen, Yu-Chen, Guo, Zi-Yuan, Abhijeet, Sambangi, Chen, Gong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046613/ https://www.ncbi.nlm.nih.gov/pubmed/32107381 http://dx.doi.org/10.1038/s41467-020-14855-3

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