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Sodium-hydrogen exchanger 6 (NHE6) deficiency leads to hearing loss, via reduced endosomal signalling through the BDNF/Trk pathway

Acid-base homeostasis is critical for normal growth, development, and hearing function. The sodium–hydrogen exchanger 6 (NHE6), a protein mainly expressed in early and recycling endosomes, plays an important role in regulating organellar pH. Mutations in NHE6 cause complex, slowly progressive neurod...

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Detalles Bibliográficos
Autores principales:	Kucharava, Krystsina, Brand, Yves, Albano, Giuseppe, Sekulic-Jablanovic, Marijana, Glutz, Andrea, Xian, Xunde, Herz, Joachim, Bodmer, Daniel, Fuster, Daniel G., Petkovic, Vesna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046661/ https://www.ncbi.nlm.nih.gov/pubmed/32107410 http://dx.doi.org/10.1038/s41598-020-60262-5

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