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Unveiling the Impact of Morphine on Tamoxifen Metabolism in Mice in vivo

Background: Tamoxifen is used to treat breast cancer and cancer recurrences. After administration, tamoxifen is converted into two more potent antitumor compounds, 4OH-tamoxifen and endoxifen by the CYP3A4/5 and 2D6 enzymes in human. These active compounds are inactivated by the same UDP-glucuronosy...

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Detalles Bibliográficos
Autores principales:	Gabel, Florian, Aubry, Anne-Sophie, Hovhannisyan, Volodya, Chavant, Virginie, Weinsanto, Ivan, Maduna, Tando, Darbon, Pascal, Goumon, Yannick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046683/ https://www.ncbi.nlm.nih.gov/pubmed/32154159 http://dx.doi.org/10.3389/fonc.2020.00025

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