Cargando…

Level of obesity is directly associated with the clinical and functional consequences of knee osteoarthritis

Obesity is one of the most important risk factors of knee osteoarthritis (KOA), but its impact on clinical and functional consequences is less clear. The main objective of this cross-sectional study was to describe the relation between body mass index (BMI) and clinical expression of KOA. Participan...

Descripción completa

Detalles Bibliográficos
Autores principales: Raud, Benjamin, Gay, Chloé, Guiguet-Auclair, Candy, Bonnin, Armand, Gerbaud, Laurent, Pereira, Bruno, Duclos, Martine, Boirie, Yves, Coudeyre, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046749/
https://www.ncbi.nlm.nih.gov/pubmed/32107449
http://dx.doi.org/10.1038/s41598-020-60587-1
_version_ 1783502014481694720
author Raud, Benjamin
Gay, Chloé
Guiguet-Auclair, Candy
Bonnin, Armand
Gerbaud, Laurent
Pereira, Bruno
Duclos, Martine
Boirie, Yves
Coudeyre, Emmanuel
author_facet Raud, Benjamin
Gay, Chloé
Guiguet-Auclair, Candy
Bonnin, Armand
Gerbaud, Laurent
Pereira, Bruno
Duclos, Martine
Boirie, Yves
Coudeyre, Emmanuel
author_sort Raud, Benjamin
collection PubMed
description Obesity is one of the most important risk factors of knee osteoarthritis (KOA), but its impact on clinical and functional consequences is less clear. The main objective of this cross-sectional study was to describe the relation between body mass index (BMI) and clinical expression of KOA. Participants with BMI ≥ 25 kg/m(2) and KOA completed anonymous self-administered questionnaires. They were classified according to BMI in three groups: overweight (BMI 25–30 kg/m(2)), stage I obesity (BMI 30–35 kg/m(2)) and stage II/III obesity (BMI ≥ 35 kg/m(2)). The groups were compared in terms of pain, physical disability, level of physical activity (PA) and fears and beliefs concerning KOA. Among the 391 individuals included, 57.0% were overweight, 28.4% had stage I obesity and 14.6% had stage II/III obesity. Mean pain score on a 10-point visual analog scale was 4.3 (SD 2.4), 5.0 (SD 2.6) and 5.2 (SD 2.3) with overweight, stage I and stage II/III obesity, respectively (p = 0.0367). The mean WOMAC function score (out of 100) was 36.2 (SD 20.1), 39.5 (SD 21.4) and 45.6 (SD 18.4), respectively (p = 0.0409). The Knee Osteoarthritis Fears and Beliefs Questionnaire total score (KOFBEQ), daily activity score and physician score significantly differed among BMI groups (p = 0.0204, p = 0.0389 and p = 0.0413, respectively), and the PA level significantly differed (p = 0.0219). We found a dose–response relation between BMI and the clinical consequences of KOA. Strategies to treat KOA should differ by obesity severity. High PA level was associated with low BMI and contributes to preventing the clinical consequences of KOA.
format Online
Article
Text
id pubmed-7046749
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-70467492020-03-05 Level of obesity is directly associated with the clinical and functional consequences of knee osteoarthritis Raud, Benjamin Gay, Chloé Guiguet-Auclair, Candy Bonnin, Armand Gerbaud, Laurent Pereira, Bruno Duclos, Martine Boirie, Yves Coudeyre, Emmanuel Sci Rep Article Obesity is one of the most important risk factors of knee osteoarthritis (KOA), but its impact on clinical and functional consequences is less clear. The main objective of this cross-sectional study was to describe the relation between body mass index (BMI) and clinical expression of KOA. Participants with BMI ≥ 25 kg/m(2) and KOA completed anonymous self-administered questionnaires. They were classified according to BMI in three groups: overweight (BMI 25–30 kg/m(2)), stage I obesity (BMI 30–35 kg/m(2)) and stage II/III obesity (BMI ≥ 35 kg/m(2)). The groups were compared in terms of pain, physical disability, level of physical activity (PA) and fears and beliefs concerning KOA. Among the 391 individuals included, 57.0% were overweight, 28.4% had stage I obesity and 14.6% had stage II/III obesity. Mean pain score on a 10-point visual analog scale was 4.3 (SD 2.4), 5.0 (SD 2.6) and 5.2 (SD 2.3) with overweight, stage I and stage II/III obesity, respectively (p = 0.0367). The mean WOMAC function score (out of 100) was 36.2 (SD 20.1), 39.5 (SD 21.4) and 45.6 (SD 18.4), respectively (p = 0.0409). The Knee Osteoarthritis Fears and Beliefs Questionnaire total score (KOFBEQ), daily activity score and physician score significantly differed among BMI groups (p = 0.0204, p = 0.0389 and p = 0.0413, respectively), and the PA level significantly differed (p = 0.0219). We found a dose–response relation between BMI and the clinical consequences of KOA. Strategies to treat KOA should differ by obesity severity. High PA level was associated with low BMI and contributes to preventing the clinical consequences of KOA. Nature Publishing Group UK 2020-02-27 /pmc/articles/PMC7046749/ /pubmed/32107449 http://dx.doi.org/10.1038/s41598-020-60587-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Raud, Benjamin
Gay, Chloé
Guiguet-Auclair, Candy
Bonnin, Armand
Gerbaud, Laurent
Pereira, Bruno
Duclos, Martine
Boirie, Yves
Coudeyre, Emmanuel
Level of obesity is directly associated with the clinical and functional consequences of knee osteoarthritis
title Level of obesity is directly associated with the clinical and functional consequences of knee osteoarthritis
title_full Level of obesity is directly associated with the clinical and functional consequences of knee osteoarthritis
title_fullStr Level of obesity is directly associated with the clinical and functional consequences of knee osteoarthritis
title_full_unstemmed Level of obesity is directly associated with the clinical and functional consequences of knee osteoarthritis
title_short Level of obesity is directly associated with the clinical and functional consequences of knee osteoarthritis
title_sort level of obesity is directly associated with the clinical and functional consequences of knee osteoarthritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046749/
https://www.ncbi.nlm.nih.gov/pubmed/32107449
http://dx.doi.org/10.1038/s41598-020-60587-1
work_keys_str_mv AT raudbenjamin levelofobesityisdirectlyassociatedwiththeclinicalandfunctionalconsequencesofkneeosteoarthritis
AT gaychloe levelofobesityisdirectlyassociatedwiththeclinicalandfunctionalconsequencesofkneeosteoarthritis
AT guiguetauclaircandy levelofobesityisdirectlyassociatedwiththeclinicalandfunctionalconsequencesofkneeosteoarthritis
AT bonninarmand levelofobesityisdirectlyassociatedwiththeclinicalandfunctionalconsequencesofkneeosteoarthritis
AT gerbaudlaurent levelofobesityisdirectlyassociatedwiththeclinicalandfunctionalconsequencesofkneeosteoarthritis
AT pereirabruno levelofobesityisdirectlyassociatedwiththeclinicalandfunctionalconsequencesofkneeosteoarthritis
AT duclosmartine levelofobesityisdirectlyassociatedwiththeclinicalandfunctionalconsequencesofkneeosteoarthritis
AT boirieyves levelofobesityisdirectlyassociatedwiththeclinicalandfunctionalconsequencesofkneeosteoarthritis
AT coudeyreemmanuel levelofobesityisdirectlyassociatedwiththeclinicalandfunctionalconsequencesofkneeosteoarthritis