Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models

Natural killer (NK) cells are the most abundant lymphocytes at the maternal-fetal interface. Epidemiological data implicate NK cells in human pregnancy outcomes. Discoveries using mouse NK cells have guided subsequent advances in human NK cell biology. However, it remains challenging to identify mou...

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Detalles Bibliográficos
Autor principal: Sojka, Dorothy K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046796/
https://www.ncbi.nlm.nih.gov/pubmed/32153593
http://dx.doi.org/10.3389/fimmu.2020.00290
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author Sojka, Dorothy K.
author_facet Sojka, Dorothy K.
author_sort Sojka, Dorothy K.
collection PubMed
description Natural killer (NK) cells are the most abundant lymphocytes at the maternal-fetal interface. Epidemiological data implicate NK cells in human pregnancy outcomes. Discoveries using mouse NK cells have guided subsequent advances in human NK cell biology. However, it remains challenging to identify mouse and human uterine NK (uNK) cell function(s) because of the dynamic changes in the systemic-endocrinological and local uterine structural microenvironments during pregnancy. This review discusses functional similarities and differences between mouse and human NK cells at the maternal-fetal interface.
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spelling pubmed-70467962020-03-09 Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models Sojka, Dorothy K. Front Immunol Immunology Natural killer (NK) cells are the most abundant lymphocytes at the maternal-fetal interface. Epidemiological data implicate NK cells in human pregnancy outcomes. Discoveries using mouse NK cells have guided subsequent advances in human NK cell biology. However, it remains challenging to identify mouse and human uterine NK (uNK) cell function(s) because of the dynamic changes in the systemic-endocrinological and local uterine structural microenvironments during pregnancy. This review discusses functional similarities and differences between mouse and human NK cells at the maternal-fetal interface. Frontiers Media S.A. 2020-02-21 /pmc/articles/PMC7046796/ /pubmed/32153593 http://dx.doi.org/10.3389/fimmu.2020.00290 Text en Copyright © 2020 Sojka. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Sojka, Dorothy K.
Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models
title Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models
title_full Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models
title_fullStr Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models
title_full_unstemmed Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models
title_short Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models
title_sort uterine natural killer cell heterogeneity: lessons from mouse models
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046796/
https://www.ncbi.nlm.nih.gov/pubmed/32153593
http://dx.doi.org/10.3389/fimmu.2020.00290
work_keys_str_mv AT sojkadorothyk uterinenaturalkillercellheterogeneitylessonsfrommousemodels

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