Alkaloid Constituents of Ficus hispida and Their Antiinflammatory Activity

Four new alkaloids, ficuhismines A–D (1–4), together with three known ones, were isolated from Ficus hispida. Their structures were elucidated by spectroscopic analysis and chemical method. The new compounds represent the first amine alkaloids with a rhamnosyl moiety (1–2) or with a N-oxide motif (2...

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Detalles Bibliográficos
Autores principales: Jia, Xin-Yu, Wu, Yong-Mei, Li, Jing-Ya, Lei, Chun, Hou, Ai-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046851/
https://www.ncbi.nlm.nih.gov/pubmed/32072482
http://dx.doi.org/10.1007/s13659-020-00233-5
Descripción
Sumario:Four new alkaloids, ficuhismines A–D (1–4), together with three known ones, were isolated from Ficus hispida. Their structures were elucidated by spectroscopic analysis and chemical method. The new compounds represent the first amine alkaloids with a rhamnosyl moiety (1–2) or with a N-oxide motif (2–4) from the genus Ficus. Compound 2 showed potent inhibitory effect in nuclear factor-κB (NF-κB) pathway luciferase assay with IC(50) value of 0.52 ± 0.11 μM. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-020-00233-5) contains supplementary material, which is available to authorized users.

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