Alkaloid Constituents of Ficus hispida and Their Antiinflammatory Activity

Four new alkaloids, ficuhismines A–D (1–4), together with three known ones, were isolated from Ficus hispida. Their structures were elucidated by spectroscopic analysis and chemical method. The new compounds represent the first amine alkaloids with a rhamnosyl moiety (1–2) or with a N-oxide motif (2...

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Autores principales: Jia, Xin-Yu, Wu, Yong-Mei, Li, Jing-Ya, Lei, Chun, Hou, Ai-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046851/
https://www.ncbi.nlm.nih.gov/pubmed/32072482
http://dx.doi.org/10.1007/s13659-020-00233-5
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author Jia, Xin-Yu
Wu, Yong-Mei
Li, Jing-Ya
Lei, Chun
Hou, Ai-Jun
author_facet Jia, Xin-Yu
Wu, Yong-Mei
Li, Jing-Ya
Lei, Chun
Hou, Ai-Jun
author_sort Jia, Xin-Yu
collection PubMed
description Four new alkaloids, ficuhismines A–D (1–4), together with three known ones, were isolated from Ficus hispida. Their structures were elucidated by spectroscopic analysis and chemical method. The new compounds represent the first amine alkaloids with a rhamnosyl moiety (1–2) or with a N-oxide motif (2–4) from the genus Ficus. Compound 2 showed potent inhibitory effect in nuclear factor-κB (NF-κB) pathway luciferase assay with IC(50) value of 0.52 ± 0.11 μM. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-020-00233-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-70468512020-03-13 Alkaloid Constituents of Ficus hispida and Their Antiinflammatory Activity Jia, Xin-Yu Wu, Yong-Mei Li, Jing-Ya Lei, Chun Hou, Ai-Jun Nat Prod Bioprospect Original Article Four new alkaloids, ficuhismines A–D (1–4), together with three known ones, were isolated from Ficus hispida. Their structures were elucidated by spectroscopic analysis and chemical method. The new compounds represent the first amine alkaloids with a rhamnosyl moiety (1–2) or with a N-oxide motif (2–4) from the genus Ficus. Compound 2 showed potent inhibitory effect in nuclear factor-κB (NF-κB) pathway luciferase assay with IC(50) value of 0.52 ± 0.11 μM. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-020-00233-5) contains supplementary material, which is available to authorized users. Springer Singapore 2020-02-18 /pmc/articles/PMC7046851/ /pubmed/32072482 http://dx.doi.org/10.1007/s13659-020-00233-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Jia, Xin-Yu
Wu, Yong-Mei
Li, Jing-Ya
Lei, Chun
Hou, Ai-Jun
Alkaloid Constituents of Ficus hispida and Their Antiinflammatory Activity
title Alkaloid Constituents of Ficus hispida and Their Antiinflammatory Activity
title_full Alkaloid Constituents of Ficus hispida and Their Antiinflammatory Activity
title_fullStr Alkaloid Constituents of Ficus hispida and Their Antiinflammatory Activity
title_full_unstemmed Alkaloid Constituents of Ficus hispida and Their Antiinflammatory Activity
title_short Alkaloid Constituents of Ficus hispida and Their Antiinflammatory Activity
title_sort alkaloid constituents of ficus hispida and their antiinflammatory activity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046851/
https://www.ncbi.nlm.nih.gov/pubmed/32072482
http://dx.doi.org/10.1007/s13659-020-00233-5
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