Cargando…

Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero

OBJECTIVE: In utero exposure of the fetus to Ro/La autoantibodies may lead to congenital heart block (CHB). In the mother, these autoantibodies are associated with activation of the type I interferon (IFN)-system. As maternal autoantibodies are transferred to the fetus during pregnancy, we investiga...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hedlund, Malin, Thorlacius, Gudny Ella, Ivanchenko, Margarita, Ottosson, Vijole, Kyriakidis, Nikolaos, Lagnefeldt, Linda, Tingström, Joanna, Sirsjö, Allan, Bengtsson, Anders A, Aronsson, Emma, Gemzell-Danielsson, Kristina, Ronnblom, Lars, Bergman, Gunnar, Espinosa, Alexander, Sonesson, Sven-Erik, Eloranta, Maija-Leena, Wahren-Herlenius, Marie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Sjögren Syndrome
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046945/ https://www.ncbi.nlm.nih.gov/pubmed/31958275 http://dx.doi.org/10.1136/rmdopen-2019-000989

Ejemplares similares

Protein and DNA methylation-based scores as surrogate markers for interferon system activation in patients with primary Sjögren’s syndrome
por: Björk, Albin, et al.
Publicado: (2020)

Antigen-driven selection of antibodies against SSA, SSB and the centromere ‘complex’, including a novel antigen, MIS12 complex, in human salivary glands
por: Takeshita, Masaru, et al.
Publicado: (2020)

Normal salivary gland ultrasonography could rule out the diagnosis of Sjögren’s syndrome in anti-SSA-negative patients with sicca syndrome
por: Al Tabaa, Omar, et al.
Publicado: (2021)

Strong Association of Combined Genetic Deficiencies in the Classical Complement Pathway With Risk of Systemic Lupus Erythematosus and Primary Sjögren's Syndrome
por: Lundtoft, Christian, et al.
Publicado: (2022)

Cigarette smoking patterns preceding primary Sjögren’s syndrome
por: Mofors, Johannes, et al.
Publicado: (2020)

Autoantigen TRIM21/Ro52 is expressed on the surface of antigen-presenting cells and its enhanced expression in Sjögren’s syndrome is associated with B cell hyperactivity and type I interferon activity
por: Hillen, Maarten R, et al.
Publicado: (2020)

Genetic variants at the RTP4/MASP1 locus are associated with fatigue in Scandinavian patients with primary Sjögren’s syndrome
por: Norheim, Katrine Brække, et al.
Publicado: (2021)

Environmental and lifestyle factors influencing risk of congenital heart block during pregnancy in anti-Ro/SSA-positive women
por: Meisgen, Sabrina, et al.
Publicado: (2017)

SIGLEC1 is a biomarker of disease activity and indicates extraglandular manifestation in primary Sjögren's syndrome
por: Rose, Thomas, et al.
Publicado: (2016)

Familial Risk of Sjögren's Syndrome and Co‐aggregation of Autoimmune Diseases in Affected Families: A Nationwide Population Study
por: Kuo, Chang‐Fu, et al.
Publicado: (2015)

Epigenetic Signatures of Salivary Gland Inflammation in Sjögren's Syndrome
por: Cole, Michael B., et al.
Publicado: (2016)

Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy
por: Bezzina, Oriana M., et al.
Publicado: (2017)

Mixed‐Methods Study Identifying Key Intervention Targets to Improve Participation in Daily Living Activities in Primary Sjögren's Syndrome Patients
por: Hackett, Katie L., et al.
Publicado: (2018)

Health-related quality of life and depression among participants in the Sjögren’s International Collaborative Clinical Alliance registry
por: Chou, Annie, et al.
Publicado: (2017)

Patient burden of Sjögren’s: a comprehensive literature review revealing the range and heterogeneity of measures used in assessments of severity
por: Hammitt, Katherine M, et al.
Publicado: (2017)

Hospitalisation rates among patients with primary Sjögren’s syndrome: a population-based study, 1995–2016
por: Maciel, Gabriel, et al.
Publicado: (2018)

Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren’s syndrome
por: Nayar, Saba, et al.
Publicado: (2019)

Increased mTORC1 activation in salivary gland B cells and T cells from patients with Sjögren’s syndrome: mTOR inhibition as a novel therapeutic strategy to halt immunopathology?
por: Blokland, Sofie L M, et al.
Publicado: (2019)

Salivary gland secretome: a novel tool towards molecular stratification of patients with primary Sjögren’s syndrome and non-autoimmune sicca
por: Blokland, Sofie L M, et al.
Publicado: (2019)

Salivary Gland Stem Cells Age Prematurely in Primary Sjögren's Syndrome
por: Pringle, Sarah, et al.
Publicado: (2018)

Sjögren’s syndrome: state of the art on clinical practice guidelines
por: Romão, Vasco C, et al.
Publicado: (2018)

Salivary gland ultrasound abnormalities in primary Sjögren’s syndrome: consensual US-SG core items definition and reliability
por: Jousse-Joulin, Sandrine, et al.
Publicado: (2017)

Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren’s syndrome
por: Hackett, Kate L, et al.
Publicado: (2019)

Salivary Gland Mucosa‐Associated Lymphoid Tissue–Type Lymphoma From Sjögren’s Syndrome Patients in the Majority Express Rheumatoid Factors Affinity‐Selected for IgG
por: Bende, Richard J., et al.
Publicado: (2020)

Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren’s syndrome with ectopic germinal centres and MALT lymphoma
por: Pontarini, Elena, et al.
Publicado: (2020)

Large granular lymphocyte expansions in primary Sjögren’s syndrome: characteristics and outcomes
por: Baber, Alistair, et al.
Publicado: (2019)

Anti-RNP positivity in primary Sjögren’s syndrome is associated with a more active disease and a more frequent muscular and pulmonary involvement
por: Abbara, Salam, et al.
Publicado: (2019)

Efficacy and safety of topical and systemic medications: a systematic literature review informing the EULAR recommendations for the management of Sjögren’s syndrome
por: Brito-Zerón, Pilar, et al.
Publicado: (2019)

Incorporation of Salivary Gland Ultrasonography Into the American College of Rheumatology/European League Against Rheumatism Criteria for Primary Sjögren's Syndrome
por: van Nimwegen, Jolien F., et al.
Publicado: (2020)

Improvement of Severe Fatigue Following Nuclease Therapy in Patients With Primary Sjögren’s Syndrome: A Randomized Clinical Trial
por: Posada, James, et al.
Publicado: (2020)

Efficacy and safety of abatacept in active primary Sjögren’s syndrome: results of a phase III, randomised, placebo-controlled trial
por: Baer, Alan N, et al.
Publicado: (2021)

Application of the OMERACT Grey-scale Ultrasound Scoring System for salivary glands in a single-centre cohort of patients with suspected Sjögren’s syndrome
por: Fana, Viktoria, et al.
Publicado: (2021)

Safety, patient acceptance and diagnostic accuracy of ultrasound core needle biopsy of parotid or submandibular glands in primary Sjögren’s syndrome with suspected salivary gland lymphoma
por: Giovannini, Ivan, et al.
Publicado: (2022)

Characteristics of Sjögren’s syndrome associated with rheumatoid arthritis
por: Hassold, Nolan, et al.
Publicado: (2022)

Proteogenomic analysis of the autoreactive B cell repertoire in blood and tissues of patients with Sjögren’s syndrome
por: Broeren, Mathijs G A, et al.
Publicado: (2022)

Immunogenicity and safety of COVID-19 vaccination in patients with primary Sjögren’s syndrome
por: Verstappen, Gwenny M, et al.
Publicado: (2022)

Lysosome-associated membrane protein 3 misexpression in salivary glands induces a Sjögren’s syndrome-like phenotype in mice
por: Nakamura, Hiroyuki, et al.
Publicado: (2021)

Sjögren’s and non-Sjögren’s sicca share a similar symptom burden but with a distinct symptom-associated proteomic signature
por: Pucino, Valentina, et al.
Publicado: (2022)

Development and preliminary validation of the Sjögren’s Tool for Assessing Response (STAR): a consensual composite score for assessing treatment effect in primary Sjögren’s syndrome
por: Seror, Raphaele, et al.
Publicado: (2022)

Symptom‐Based Cluster Analysis Categorizes Sjögren's Disease Subtypes: An International Cohort Study Highlighting Disease Severity and Treatment Discordance
por: McCoy, Sara S., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_d9hq0gjb88l99t1b1udgrphfk6