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Pathogenesis of ischaemic and non-ischaemic heart diseases in rheumatoid arthritis

Rheumatoid arthritis (RA) is characterised by a chronic inflammatory condition of the joints, but the comorbidities of RA predominantly contribute to the reduced lifespan associated with this disease. Clinical data indicate that cardiovascular disease is the major comorbidity associated with mortali...

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Autores principales: Błyszczuk, Przemysław, Szekanecz, Zoltan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046979/
https://www.ncbi.nlm.nih.gov/pubmed/31958278
http://dx.doi.org/10.1136/rmdopen-2019-001032
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author Błyszczuk, Przemysław
Szekanecz, Zoltan
author_facet Błyszczuk, Przemysław
Szekanecz, Zoltan
author_sort Błyszczuk, Przemysław
collection PubMed
description Rheumatoid arthritis (RA) is characterised by a chronic inflammatory condition of the joints, but the comorbidities of RA predominantly contribute to the reduced lifespan associated with this disease. Clinical data indicate that cardiovascular disease is the major comorbidity associated with mortality in RA. In this review, we aimed to describe the pathogenesis of heart failure in RA. First, we emphasised the fundamental differences between ischaemic and non-ischaemic heart diseases and referred to their relevance in excessive cardiovascular-dependent mortality in RA. Second, we highlighted aspects of asymptomatic changes in cardiac tissue and in coronary blood vessels that are commonly found in patients with diagnosed RA. Third, we focused on high-grade systemic inflammation as a key trigger of ischaemic and non-ischaemic heart diseases in RA, and described the implication of conventional and biologic antirheumatic medications on the development and progression of heart disease. In particular, we discussed the roles of tumour necrosis factor-alpha (TNF-α) and anti-TNF-α therapies on the development and progression of ischaemic and non-ischaemic heart diseases in RA.
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spelling pubmed-70469792020-03-09 Pathogenesis of ischaemic and non-ischaemic heart diseases in rheumatoid arthritis Błyszczuk, Przemysław Szekanecz, Zoltan RMD Open Rheumatoid Arthritis Rheumatoid arthritis (RA) is characterised by a chronic inflammatory condition of the joints, but the comorbidities of RA predominantly contribute to the reduced lifespan associated with this disease. Clinical data indicate that cardiovascular disease is the major comorbidity associated with mortality in RA. In this review, we aimed to describe the pathogenesis of heart failure in RA. First, we emphasised the fundamental differences between ischaemic and non-ischaemic heart diseases and referred to their relevance in excessive cardiovascular-dependent mortality in RA. Second, we highlighted aspects of asymptomatic changes in cardiac tissue and in coronary blood vessels that are commonly found in patients with diagnosed RA. Third, we focused on high-grade systemic inflammation as a key trigger of ischaemic and non-ischaemic heart diseases in RA, and described the implication of conventional and biologic antirheumatic medications on the development and progression of heart disease. In particular, we discussed the roles of tumour necrosis factor-alpha (TNF-α) and anti-TNF-α therapies on the development and progression of ischaemic and non-ischaemic heart diseases in RA. BMJ Publishing Group 2020-01-07 /pmc/articles/PMC7046979/ /pubmed/31958278 http://dx.doi.org/10.1136/rmdopen-2019-001032 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Rheumatoid Arthritis
Błyszczuk, Przemysław
Szekanecz, Zoltan
Pathogenesis of ischaemic and non-ischaemic heart diseases in rheumatoid arthritis
title Pathogenesis of ischaemic and non-ischaemic heart diseases in rheumatoid arthritis
title_full Pathogenesis of ischaemic and non-ischaemic heart diseases in rheumatoid arthritis
title_fullStr Pathogenesis of ischaemic and non-ischaemic heart diseases in rheumatoid arthritis
title_full_unstemmed Pathogenesis of ischaemic and non-ischaemic heart diseases in rheumatoid arthritis
title_short Pathogenesis of ischaemic and non-ischaemic heart diseases in rheumatoid arthritis
title_sort pathogenesis of ischaemic and non-ischaemic heart diseases in rheumatoid arthritis
topic Rheumatoid Arthritis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046979/
https://www.ncbi.nlm.nih.gov/pubmed/31958278
http://dx.doi.org/10.1136/rmdopen-2019-001032
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