ZHX2 restricts hepatocellular carcinoma by suppressing stem cell-like traits through KDM2A-mediated H3K36 demethylation

BACKGROUND: Liver cancer stem cells (CSCs) are critical determinants of HCC relapse and therapeutic resistance, but the mechanisms underlying the maintenance of CSCs are poorly understood. We aimed to explore the role of tumor repressor Zinc-fingers and homeoboxes 2 (ZHX2) in liver CSCs. METHODS: CD...

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Detalles Bibliográficos
Autores principales: Lin, Qinghai, Wu, Zhuanchang, Yue, Xuetian, Yu, Xiangguo, Wang, Zehua, Song, Xiaojia, Xu, Leiqi, He, Ying, Ge, Yutong, Tan, Siyu, Wang, Tixiao, Song, Hui, Yuan, Detian, Gong, Yaoqin, Gao, Lifen, Liang, Xiaohong, Ma, Chunhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047184/
https://www.ncbi.nlm.nih.gov/pubmed/32114388
http://dx.doi.org/10.1016/j.ebiom.2020.102676

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