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Colorimetric Band-aids for Point-of-Care Sensing and Treating Bacterial Infection
[Image: see text] Sensing bacterial infections and monitoring drug resistance are very important for the selection of treatment options. However, the common methods of sensing resistance are limited by time-consuming, the requirement for professional personnel, and expensive instruments. Moreover, t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047266/ https://www.ncbi.nlm.nih.gov/pubmed/32123738 http://dx.doi.org/10.1021/acscentsci.9b01104 |
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author | Sun, Yuhuan Zhao, Chuanqi Niu, Jingsheng Ren, Jinsong Qu, Xiaogang |
author_facet | Sun, Yuhuan Zhao, Chuanqi Niu, Jingsheng Ren, Jinsong Qu, Xiaogang |
author_sort | Sun, Yuhuan |
collection | PubMed |
description | [Image: see text] Sensing bacterial infections and monitoring drug resistance are very important for the selection of treatment options. However, the common methods of sensing resistance are limited by time-consuming, the requirement for professional personnel, and expensive instruments. Moreover, the abuse of antibiotics causes the accelerated process of bacterial resistance. Herein, we construct a portable paper-based band-aid (PBA) which implements a selective antibacterial strategy after sensing of drug resistance. The colors of PBA indicate bacterial infection (yellow) and drug resistance (red), just like a bacterial resistance colorimetric card. On the basis of color, antibiotic-based chemotherapy and Zr-MOF PCN-224-based photodynamic therapy (PDT) are used on site to treat sensitive and resistant strains, respectively. Eventually, it takes 4 h to sense, and the limit of detection is 10(4) CFU/mL for drug-resistant E. coli. Compared with traditional PDT-based antibacterial strategies, our design can alleviate off-target side effects, maximize therapeutic efficacy, and track the drug resistance in real time with the naked eye. This work develops a new way for the rational use of antibiotics. Given the low cost and easy operation of this point-of-care device, it can be developed for practical applications. |
format | Online Article Text |
id | pubmed-7047266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-70472662020-03-02 Colorimetric Band-aids for Point-of-Care Sensing and Treating Bacterial Infection Sun, Yuhuan Zhao, Chuanqi Niu, Jingsheng Ren, Jinsong Qu, Xiaogang ACS Cent Sci [Image: see text] Sensing bacterial infections and monitoring drug resistance are very important for the selection of treatment options. However, the common methods of sensing resistance are limited by time-consuming, the requirement for professional personnel, and expensive instruments. Moreover, the abuse of antibiotics causes the accelerated process of bacterial resistance. Herein, we construct a portable paper-based band-aid (PBA) which implements a selective antibacterial strategy after sensing of drug resistance. The colors of PBA indicate bacterial infection (yellow) and drug resistance (red), just like a bacterial resistance colorimetric card. On the basis of color, antibiotic-based chemotherapy and Zr-MOF PCN-224-based photodynamic therapy (PDT) are used on site to treat sensitive and resistant strains, respectively. Eventually, it takes 4 h to sense, and the limit of detection is 10(4) CFU/mL for drug-resistant E. coli. Compared with traditional PDT-based antibacterial strategies, our design can alleviate off-target side effects, maximize therapeutic efficacy, and track the drug resistance in real time with the naked eye. This work develops a new way for the rational use of antibiotics. Given the low cost and easy operation of this point-of-care device, it can be developed for practical applications. American Chemical Society 2020-01-29 2020-02-26 /pmc/articles/PMC7047266/ /pubmed/32123738 http://dx.doi.org/10.1021/acscentsci.9b01104 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Sun, Yuhuan Zhao, Chuanqi Niu, Jingsheng Ren, Jinsong Qu, Xiaogang Colorimetric Band-aids for Point-of-Care Sensing and Treating Bacterial Infection |
title | Colorimetric Band-aids for Point-of-Care Sensing and
Treating Bacterial Infection |
title_full | Colorimetric Band-aids for Point-of-Care Sensing and
Treating Bacterial Infection |
title_fullStr | Colorimetric Band-aids for Point-of-Care Sensing and
Treating Bacterial Infection |
title_full_unstemmed | Colorimetric Band-aids for Point-of-Care Sensing and
Treating Bacterial Infection |
title_short | Colorimetric Band-aids for Point-of-Care Sensing and
Treating Bacterial Infection |
title_sort | colorimetric band-aids for point-of-care sensing and
treating bacterial infection |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047266/ https://www.ncbi.nlm.nih.gov/pubmed/32123738 http://dx.doi.org/10.1021/acscentsci.9b01104 |
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