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Competitive Metabolite Profiling of Natural Products Reveals Subunit Specific Inhibitors of the 20S Proteasome

[Image: see text] We have developed a syringolin-based chemical probe and explored its utility for the profiling of metabolite extracts as potent inhibitors of the 20S proteasome. Activity-guided fractionation by competitive labeling allowed us to isolate and identify glidobactin A and C as well as...

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Detalles Bibliográficos
Autores principales:	Pawar, Atul, Basler, Michael, Goebel, Heike, Alvarez Salinas, Gerardo Omar, Groettrup, Marcus, Böttcher, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047272/ https://www.ncbi.nlm.nih.gov/pubmed/32123742 http://dx.doi.org/10.1021/acscentsci.9b01170

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