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Synergistic Signaling of TLR and IFNα/β Facilitates Escape of IL-18 Expression from Endotoxin Tolerance

Rationale: IL-18 is a member of the IL-1 cytokine family, and elevated blood IL-18 concentrations associate with disease activity in macrophage activation syndrome (MAS) and poor clinical outcomes in severe inflammatory and septic conditions. Objectives: Although recent investigations provide mechan...

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Detalles Bibliográficos
Autores principales:	Verweyen, Emely, Holzinger, Dirk, Weinhage, Toni, Hinze, Claas, Wittkowski, Helmut, Pickkers, Peter, Albeituni, Sabrin, Verbist, Katherine, Nichols, Kim E., Schulert, Grant, Grom, Alexei, Foell, Dirk, Kessel, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Thoracic Society 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047449/ https://www.ncbi.nlm.nih.gov/pubmed/31710506 http://dx.doi.org/10.1164/rccm.201903-0659OC

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