Initiating Resuscitation Before Umbilical Cord Clamping in Infants with Congenital Diaphragmatic Hernia: A Pilot Feasibility Trial

BACKGROUND: Infants with congenital diaphragmatic hernia (CDH) often experience hypoxemia with acidosis immediately after birth. The traditional approach in the delivery room is immediate cord clamping followed by intubation. Initiating resuscitation prior to umbilical cord clamping (UCC) may support this transition. OBJECTIVES: To establish the safety and feasibility of intubation and ventilation prior to UCC for infants with CDH. To compare short-term outcomes between trial participants and matched controls treated with immediate cord clamping before intubation and ventilation. DESIGN: Single-arm, single site trial of infants with CDH and gestational age ≥ 36 weeks. Infants were placed on a trolley immediately after birth and underwent intubation and ventilation, with UCC performed after qualitative CO(2) detection. The primary feasibility endpoint was successful intubation prior to UCC. Prespecified safety and physiologic outcomes were compared with historical controls matched for prognostic variables using standard bivariate tests. RESULTS: Of 20 enrolled infants, all were placed on the trolley and 17 (85%) were intubated before UCC. The first hemoglobin and mean blood pressure at 1 hour of life were significantly higher in trial participants than controls. There were no significant differences between groups for subsequent blood pressure values, vasoactive medications, inhaled nitric oxide, or ECMO. Blood gas and oxygenation index values did not differ between groups at any point. CONCLUSIONS: Intubation and ventilation prior to UCC is safe and feasible among infants with CDH. The impact of this approach on clinically relevant outcomes deserves investigation in a randomized trial.