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Quinolinate as a Marker for Kynurenine Metabolite Formation and the Unresolved Question of NAD(+) Synthesis During Inflammation and Infection

Quinolinate (Quin) is a classic example of a biochemical double-edged sword, acting as both essential metabolite and potent neurotoxin. Quin is an important metabolite in the kynurenine pathway of tryptophan catabolism leading to the de novo synthesis of nicotinamide adenine dinucleotide (NAD(+)). A...

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Detalles Bibliográficos
Autores principales:	Moffett, John R., Arun, Peethambaran, Puthillathu, Narayanan, Vengilote, Ranjini, Ives, John A., Badawy, Abdulla A-B, Namboodiri, Aryan M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047773/ https://www.ncbi.nlm.nih.gov/pubmed/32153556 http://dx.doi.org/10.3389/fimmu.2020.00031

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