Cryo-EM Structures of Four Polymorphic TDP-43 Amyloid Cores

The DNA/RNA processing protein TDP-43 undergoes both functional and pathogennic aggregation. Functional TDP-43 aggregates form reversible, transient species such as nuclear bodies, stress granules, and myo-granules. Pathogenic, irreversible TDP-43 aggregates form in amyotrophic lateral sclerosis (AL...

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Detalles Bibliográficos
Autores principales: Cao, Qin, Boyer, David R., Sawaya, Michael R., Ge, Peng, Eisenberg, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047951/
https://www.ncbi.nlm.nih.gov/pubmed/31235914
http://dx.doi.org/10.1038/s41594-019-0248-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047951/
https://www.ncbi.nlm.nih.gov/pubmed/31235914
http://dx.doi.org/10.1038/s41594-019-0248-4

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