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Cryo-EM Structures of Four Polymorphic TDP-43 Amyloid Cores
The DNA/RNA processing protein TDP-43 undergoes both functional and pathogennic aggregation. Functional TDP-43 aggregates form reversible, transient species such as nuclear bodies, stress granules, and myo-granules. Pathogenic, irreversible TDP-43 aggregates form in amyotrophic lateral sclerosis (AL...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047951/ https://www.ncbi.nlm.nih.gov/pubmed/31235914 http://dx.doi.org/10.1038/s41594-019-0248-4 |