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Do current approaches to assessing therapy related adverse events align with the needs of long-term cancer patients and survivors?

The increasing efficacy of cancer therapeutics means that the timespan of cancer therapy administration is undergoing a transition to increasingly long-term settings. Unfortunately, chronic therapy-related adverse health events are an unintended, but not infrequent, outcome of these life-saving ther...

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Autores principales: Pettit, Syril D., Kirch, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048033/
https://www.ncbi.nlm.nih.gov/pubmed/32154005
http://dx.doi.org/10.1186/s40959-018-0031-4
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author Pettit, Syril D.
Kirch, Rebecca
author_facet Pettit, Syril D.
Kirch, Rebecca
author_sort Pettit, Syril D.
collection PubMed
description The increasing efficacy of cancer therapeutics means that the timespan of cancer therapy administration is undergoing a transition to increasingly long-term settings. Unfortunately, chronic therapy-related adverse health events are an unintended, but not infrequent, outcome of these life-saving therapies. Historically, the cardio-oncology field has evolved as retrospective effort to understand the scope, mechanisms, and impact of treatment-related toxicities that were already impacting patients. This review explores whether current systemic approaches to detecting, reporting, tracking, and communicating AEs are better positioned to provide more proactive or concurrent information to mitigate the impact of AE’s on patient health and quality of life. Because the existing tools and frameworks for capturing these effects are not specific to cardiology, this study looks broadly at the landscape of approaches and assumptions. This review finds evidence of increasing focus on the provision of actionable information to support long-term health and quality of life for survivors and those on chronic therapy. However, the current means to assess and support the impact of this burden on patients and the healthcare system are often of limited relevance for an increasingly long-lived survivor and patient population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40959-018-0031-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-70480332020-03-09 Do current approaches to assessing therapy related adverse events align with the needs of long-term cancer patients and survivors? Pettit, Syril D. Kirch, Rebecca Cardiooncology Review The increasing efficacy of cancer therapeutics means that the timespan of cancer therapy administration is undergoing a transition to increasingly long-term settings. Unfortunately, chronic therapy-related adverse health events are an unintended, but not infrequent, outcome of these life-saving therapies. Historically, the cardio-oncology field has evolved as retrospective effort to understand the scope, mechanisms, and impact of treatment-related toxicities that were already impacting patients. This review explores whether current systemic approaches to detecting, reporting, tracking, and communicating AEs are better positioned to provide more proactive or concurrent information to mitigate the impact of AE’s on patient health and quality of life. Because the existing tools and frameworks for capturing these effects are not specific to cardiology, this study looks broadly at the landscape of approaches and assumptions. This review finds evidence of increasing focus on the provision of actionable information to support long-term health and quality of life for survivors and those on chronic therapy. However, the current means to assess and support the impact of this burden on patients and the healthcare system are often of limited relevance for an increasingly long-lived survivor and patient population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40959-018-0031-4) contains supplementary material, which is available to authorized users. BioMed Central 2018-06-15 /pmc/articles/PMC7048033/ /pubmed/32154005 http://dx.doi.org/10.1186/s40959-018-0031-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Pettit, Syril D.
Kirch, Rebecca
Do current approaches to assessing therapy related adverse events align with the needs of long-term cancer patients and survivors?
title Do current approaches to assessing therapy related adverse events align with the needs of long-term cancer patients and survivors?
title_full Do current approaches to assessing therapy related adverse events align with the needs of long-term cancer patients and survivors?
title_fullStr Do current approaches to assessing therapy related adverse events align with the needs of long-term cancer patients and survivors?
title_full_unstemmed Do current approaches to assessing therapy related adverse events align with the needs of long-term cancer patients and survivors?
title_short Do current approaches to assessing therapy related adverse events align with the needs of long-term cancer patients and survivors?
title_sort do current approaches to assessing therapy related adverse events align with the needs of long-term cancer patients and survivors?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048033/
https://www.ncbi.nlm.nih.gov/pubmed/32154005
http://dx.doi.org/10.1186/s40959-018-0031-4
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