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Evaluation of surrogacy in the multi-trial setting based on information theory: an extension to ordinal outcomes
Summary: In clinical trials, surrogate outcomes are early measures of treatment effect that are used to predict treatment effect on a later primary outcome of interest: the primary outcome therefore does not need to be observed and trials can be shortened. Evaluating surrogates is a complex area as...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048082/ https://www.ncbi.nlm.nih.gov/pubmed/31887069 http://dx.doi.org/10.1080/10543406.2019.1696357 |
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author | Ensor, Hannah Weir, Christopher J. |
author_facet | Ensor, Hannah Weir, Christopher J. |
author_sort | Ensor, Hannah |
collection | PubMed |
description | Summary: In clinical trials, surrogate outcomes are early measures of treatment effect that are used to predict treatment effect on a later primary outcome of interest: the primary outcome therefore does not need to be observed and trials can be shortened. Evaluating surrogates is a complex area as a given treatment can act through multiple pathways, some of which may circumvent the surrogate. One of the best established and practically sound approaches to surrogacy evaluation is based on information theory. We have extended this approach to the case of ordinal outcomes, which are used as primary outcomes in many medical areas. This extension provides researchers with the means of evaluating surrogates in this setting, which expands the usefulness of the information theory approach while also demonstrating its versatility. |
format | Online Article Text |
id | pubmed-7048082 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-70480822020-03-16 Evaluation of surrogacy in the multi-trial setting based on information theory: an extension to ordinal outcomes Ensor, Hannah Weir, Christopher J. J Biopharm Stat Article Summary: In clinical trials, surrogate outcomes are early measures of treatment effect that are used to predict treatment effect on a later primary outcome of interest: the primary outcome therefore does not need to be observed and trials can be shortened. Evaluating surrogates is a complex area as a given treatment can act through multiple pathways, some of which may circumvent the surrogate. One of the best established and practically sound approaches to surrogacy evaluation is based on information theory. We have extended this approach to the case of ordinal outcomes, which are used as primary outcomes in many medical areas. This extension provides researchers with the means of evaluating surrogates in this setting, which expands the usefulness of the information theory approach while also demonstrating its versatility. Taylor & Francis 2019-12-30 /pmc/articles/PMC7048082/ /pubmed/31887069 http://dx.doi.org/10.1080/10543406.2019.1696357 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Ensor, Hannah Weir, Christopher J. Evaluation of surrogacy in the multi-trial setting based on information theory: an extension to ordinal outcomes |
title | Evaluation of surrogacy in the multi-trial setting based on information theory: an extension to ordinal outcomes |
title_full | Evaluation of surrogacy in the multi-trial setting based on information theory: an extension to ordinal outcomes |
title_fullStr | Evaluation of surrogacy in the multi-trial setting based on information theory: an extension to ordinal outcomes |
title_full_unstemmed | Evaluation of surrogacy in the multi-trial setting based on information theory: an extension to ordinal outcomes |
title_short | Evaluation of surrogacy in the multi-trial setting based on information theory: an extension to ordinal outcomes |
title_sort | evaluation of surrogacy in the multi-trial setting based on information theory: an extension to ordinal outcomes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048082/ https://www.ncbi.nlm.nih.gov/pubmed/31887069 http://dx.doi.org/10.1080/10543406.2019.1696357 |
work_keys_str_mv | AT ensorhannah evaluationofsurrogacyinthemultitrialsettingbasedoninformationtheoryanextensiontoordinaloutcomes AT weirchristopherj evaluationofsurrogacyinthemultitrialsettingbasedoninformationtheoryanextensiontoordinaloutcomes |