5-FU induced cardiotoxicity: case series and review of the literature

BACKGROUND: 5-Fluorouracil (5-FU) is an antimetabolite chemotherapy used for a variety of solid tumors. It has the potential to cause a wide spectrum of cardiotoxicity, ranging from asymptomatic electrocardiographic changes to cardiomyopathy and subsequent cardiac failure. Main body of the abstract:...

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Autores principales: Yuan, Cai, Parekh, Hiral, Allegra, Carmen, George, Thomas J., Starr, Jason S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048125/
https://www.ncbi.nlm.nih.gov/pubmed/32154019
http://dx.doi.org/10.1186/s40959-019-0048-3
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author Yuan, Cai
Parekh, Hiral
Allegra, Carmen
George, Thomas J.
Starr, Jason S.
author_facet Yuan, Cai
Parekh, Hiral
Allegra, Carmen
George, Thomas J.
Starr, Jason S.
author_sort Yuan, Cai
collection PubMed
description BACKGROUND: 5-Fluorouracil (5-FU) is an antimetabolite chemotherapy used for a variety of solid tumors. It has the potential to cause a wide spectrum of cardiotoxicity, ranging from asymptomatic electrocardiographic changes to cardiomyopathy and subsequent cardiac failure. Main body of the abstract: We present two descriptive cases of new-onset severe cardiomyopathy induced by 5-FU followed by a review of the literature. CONCLUSION: Our case series emphasizes the importance of early recognition of this rare complication and prompt cessation of 5-FU, as cardiac dysfunction in this context is potentially reversible.
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spelling pubmed-70481252020-03-09 5-FU induced cardiotoxicity: case series and review of the literature Yuan, Cai Parekh, Hiral Allegra, Carmen George, Thomas J. Starr, Jason S. Cardiooncology Review BACKGROUND: 5-Fluorouracil (5-FU) is an antimetabolite chemotherapy used for a variety of solid tumors. It has the potential to cause a wide spectrum of cardiotoxicity, ranging from asymptomatic electrocardiographic changes to cardiomyopathy and subsequent cardiac failure. Main body of the abstract: We present two descriptive cases of new-onset severe cardiomyopathy induced by 5-FU followed by a review of the literature. CONCLUSION: Our case series emphasizes the importance of early recognition of this rare complication and prompt cessation of 5-FU, as cardiac dysfunction in this context is potentially reversible. BioMed Central 2019-09-06 /pmc/articles/PMC7048125/ /pubmed/32154019 http://dx.doi.org/10.1186/s40959-019-0048-3 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Yuan, Cai
Parekh, Hiral
Allegra, Carmen
George, Thomas J.
Starr, Jason S.
5-FU induced cardiotoxicity: case series and review of the literature
title 5-FU induced cardiotoxicity: case series and review of the literature
title_full 5-FU induced cardiotoxicity: case series and review of the literature
title_fullStr 5-FU induced cardiotoxicity: case series and review of the literature
title_full_unstemmed 5-FU induced cardiotoxicity: case series and review of the literature
title_short 5-FU induced cardiotoxicity: case series and review of the literature
title_sort 5-fu induced cardiotoxicity: case series and review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048125/
https://www.ncbi.nlm.nih.gov/pubmed/32154019
http://dx.doi.org/10.1186/s40959-019-0048-3
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