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Single-cell transcriptome analysis reveals TOX as a promoting factor for T cell exhaustion and a predictor for anti-PD-1 responses in human cancer

BACKGROUND: T cells exhibit heterogeneous functional states in the tumor microenvironment. Immune checkpoint inhibitors (ICIs) can reinvigorate only the stem cell-like progenitor exhausted T cells, which suggests that inhibiting the exhaustion progress will improve the efficacy of immunotherapy. Thu...

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Detalles Bibliográficos
Autores principales:	Kim, Kyungsoo, Park, Seyeon, Park, Seong Yong, Kim, Gamin, Park, Su Myeong, Cho, Jae-Won, Kim, Da Hee, Park, Young Min, Koh, Yoon Woo, Kim, Hye Ryun, Ha, Sang-Jun, Lee, Insuk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048139/ https://www.ncbi.nlm.nih.gov/pubmed/32111241 http://dx.doi.org/10.1186/s13073-020-00722-9

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