The Role of Pentraxin 3 in Aspergillosis: Reality and Prospects

Pentraxin 3 (PTX3) is a soluble pattern recognition receptor (PRR), which is produced by several kinds of cells, such as neutrophils, dendritic cells, macrophages, and epithelial cells. PTX3 is known to play an important protective effect against Aspergillus. Genetic linkage in gene-targeted mice an...

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Detalles Bibliográficos
Autores principales: Kang, Yuening, Yu, Yuetian, Lu, Liangjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048186/
https://www.ncbi.nlm.nih.gov/pubmed/32158600
http://dx.doi.org/10.1080/12298093.2020.1722576
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author Kang, Yuening
Yu, Yuetian
Lu, Liangjing
author_facet Kang, Yuening
Yu, Yuetian
Lu, Liangjing
author_sort Kang, Yuening
collection PubMed
description Pentraxin 3 (PTX3) is a soluble pattern recognition receptor (PRR), which is produced by several kinds of cells, such as neutrophils, dendritic cells, macrophages, and epithelial cells. PTX3 is known to play an important protective effect against Aspergillus. Genetic linkage in gene-targeted mice and human PTX3 plays a non-redundant role in the immune protection against specific pathogens, especially Aspergillus. Recent studies have shown that the polymorphism of PTX3 is associated with increased susceptibility to invasive aspergillosis (IA). In this review, we provide an overview of these studies that underline the potential of PTX3 in diagnosis and therapy of IA.
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spelling pubmed-70481862020-03-10 The Role of Pentraxin 3 in Aspergillosis: Reality and Prospects Kang, Yuening Yu, Yuetian Lu, Liangjing Mycobiology Review Article Pentraxin 3 (PTX3) is a soluble pattern recognition receptor (PRR), which is produced by several kinds of cells, such as neutrophils, dendritic cells, macrophages, and epithelial cells. PTX3 is known to play an important protective effect against Aspergillus. Genetic linkage in gene-targeted mice and human PTX3 plays a non-redundant role in the immune protection against specific pathogens, especially Aspergillus. Recent studies have shown that the polymorphism of PTX3 is associated with increased susceptibility to invasive aspergillosis (IA). In this review, we provide an overview of these studies that underline the potential of PTX3 in diagnosis and therapy of IA. Taylor & Francis 2020-02-08 /pmc/articles/PMC7048186/ /pubmed/32158600 http://dx.doi.org/10.1080/12298093.2020.1722576 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of the Korean Society of Mycology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kang, Yuening
Yu, Yuetian
Lu, Liangjing
The Role of Pentraxin 3 in Aspergillosis: Reality and Prospects
title The Role of Pentraxin 3 in Aspergillosis: Reality and Prospects
title_full The Role of Pentraxin 3 in Aspergillosis: Reality and Prospects
title_fullStr The Role of Pentraxin 3 in Aspergillosis: Reality and Prospects
title_full_unstemmed The Role of Pentraxin 3 in Aspergillosis: Reality and Prospects
title_short The Role of Pentraxin 3 in Aspergillosis: Reality and Prospects
title_sort role of pentraxin 3 in aspergillosis: reality and prospects
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048186/
https://www.ncbi.nlm.nih.gov/pubmed/32158600
http://dx.doi.org/10.1080/12298093.2020.1722576
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