Lack of an association between clinical INSTI-related body weight gain and direct interference with MC4 receptor (MC4R), a key central regulator of body weight

An increasing prevalence of overweight and obesity in people living with HIV has been associated with initiation of antiretroviral therapy with integrase strand transfer inhibitors (INSTIs). An off-target inhibition of the endogenous ligand binding to the human melanocortin 4 receptor (MC4R) has bee...

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Detalles Bibliográficos
Autores principales: McMahon, Carrie, Trevaskis, James L., Carter, Christoph, Holsapple, Kevin, White, Kirsten, Das, Moupali, Collins, Sean, Martin, Hal, Burns-Naas, Leigh Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048285/
https://www.ncbi.nlm.nih.gov/pubmed/32109250
http://dx.doi.org/10.1371/journal.pone.0229617

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