PGC‐1α overexpression increases transcription factor EB nuclear localization and lysosome abundance in dystrophin‐deficient skeletal muscle

Duchenne muscular dystrophy (DMD) is caused by the absence of functional dystrophin protein and results in progressive muscle wasting. Dystrophin deficiency leads to a host of dysfunctional cellular processes including impaired autophagy. Autophagic dysfunction appears to be due, at least in part, t...

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Detalles Bibliográficos
Autores principales: Spaulding, Hannah R., Ludwig, Amanda K., Hollinger, Katrin, Hudson, Matthew B., Selsby, Joshua T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048376/
https://www.ncbi.nlm.nih.gov/pubmed/32109352
http://dx.doi.org/10.14814/phy2.14383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048376/
https://www.ncbi.nlm.nih.gov/pubmed/32109352
http://dx.doi.org/10.14814/phy2.14383

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