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Comparison of Continuous Epidural Infusion of Bupivacaine and Fentanyl Versus Patient Controlled Analgesia Techniques for Labor Analgesia: A Randomized Controlled Trial (RCT)

BACKGROUND: To diminish labor pain, several techniques have been used in developed countries. In the current randomized controlled trial, the use of epidural analgesia via PCEA pump with and without background infusion of analgesic was studied. METHODS: In this double-blinded controlled trial, 60 wo...

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Autores principales: Khaneshi, Raha, Rasooli, Sousan, Moslemi, Farnaz, Fakour, Sanam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Research Institute 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048688/
https://www.ncbi.nlm.nih.gov/pubmed/32175264
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author Khaneshi, Raha
Rasooli, Sousan
Moslemi, Farnaz
Fakour, Sanam
author_facet Khaneshi, Raha
Rasooli, Sousan
Moslemi, Farnaz
Fakour, Sanam
author_sort Khaneshi, Raha
collection PubMed
description BACKGROUND: To diminish labor pain, several techniques have been used in developed countries. In the current randomized controlled trial, the use of epidural analgesia via PCEA pump with and without background infusion of analgesic was studied. METHODS: In this double-blinded controlled trial, 60 women were enrolled and randomly assigned to study groups for receiving epidural analgesia during labor. All patients received initial bullous dose including 125 mg bupivacaine and 3 mg/ml fentanyl, and the first group patient (CI) received background infusion of 8 ml/hr and the second group (PCEA) received 10 ml bullous dose of 125 mg bupivacaine combined with 100 mcg fentanyl (2 ml) via epidural catheter. The Visual Analogue Scale (VAS) of 0–10 was measured 20 min after drug injection. The chi-square and student T-test were used for comparing variables between groups, and 0.05 was considered as the level of significance. RESULTS: There was no significant difference in terms of demographic variables. Mean duration of the second stage of labor was significantly lower in patients received continuous infusion (CI) (p<0.0001). However, the total administered fentanyl dose was significantly higher in patients who underwent PCEA (p<0.0001). Besides, the CI group had a significantly lower rate of patient-controlled injection compared to PCEA patients (p<0.0001). However, there was no significant difference between patients’ satisfaction and VAS in study groups. CONCLUSION: Epidural analgesia using PCEA combined with continuous infusion did not provide higher analgesia or patients’ satisfaction compared to PCEA alone; however, it led to a decreased rate of drug injection and total administered dosage.
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spelling pubmed-70486882020-03-13 Comparison of Continuous Epidural Infusion of Bupivacaine and Fentanyl Versus Patient Controlled Analgesia Techniques for Labor Analgesia: A Randomized Controlled Trial (RCT) Khaneshi, Raha Rasooli, Sousan Moslemi, Farnaz Fakour, Sanam J Reprod Infertil Original Article BACKGROUND: To diminish labor pain, several techniques have been used in developed countries. In the current randomized controlled trial, the use of epidural analgesia via PCEA pump with and without background infusion of analgesic was studied. METHODS: In this double-blinded controlled trial, 60 women were enrolled and randomly assigned to study groups for receiving epidural analgesia during labor. All patients received initial bullous dose including 125 mg bupivacaine and 3 mg/ml fentanyl, and the first group patient (CI) received background infusion of 8 ml/hr and the second group (PCEA) received 10 ml bullous dose of 125 mg bupivacaine combined with 100 mcg fentanyl (2 ml) via epidural catheter. The Visual Analogue Scale (VAS) of 0–10 was measured 20 min after drug injection. The chi-square and student T-test were used for comparing variables between groups, and 0.05 was considered as the level of significance. RESULTS: There was no significant difference in terms of demographic variables. Mean duration of the second stage of labor was significantly lower in patients received continuous infusion (CI) (p<0.0001). However, the total administered fentanyl dose was significantly higher in patients who underwent PCEA (p<0.0001). Besides, the CI group had a significantly lower rate of patient-controlled injection compared to PCEA patients (p<0.0001). However, there was no significant difference between patients’ satisfaction and VAS in study groups. CONCLUSION: Epidural analgesia using PCEA combined with continuous infusion did not provide higher analgesia or patients’ satisfaction compared to PCEA alone; however, it led to a decreased rate of drug injection and total administered dosage. Avicenna Research Institute 2020 /pmc/articles/PMC7048688/ /pubmed/32175264 Text en Copyright© 2020, Avicenna Research Institute. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Khaneshi, Raha
Rasooli, Sousan
Moslemi, Farnaz
Fakour, Sanam
Comparison of Continuous Epidural Infusion of Bupivacaine and Fentanyl Versus Patient Controlled Analgesia Techniques for Labor Analgesia: A Randomized Controlled Trial (RCT)
title Comparison of Continuous Epidural Infusion of Bupivacaine and Fentanyl Versus Patient Controlled Analgesia Techniques for Labor Analgesia: A Randomized Controlled Trial (RCT)
title_full Comparison of Continuous Epidural Infusion of Bupivacaine and Fentanyl Versus Patient Controlled Analgesia Techniques for Labor Analgesia: A Randomized Controlled Trial (RCT)
title_fullStr Comparison of Continuous Epidural Infusion of Bupivacaine and Fentanyl Versus Patient Controlled Analgesia Techniques for Labor Analgesia: A Randomized Controlled Trial (RCT)
title_full_unstemmed Comparison of Continuous Epidural Infusion of Bupivacaine and Fentanyl Versus Patient Controlled Analgesia Techniques for Labor Analgesia: A Randomized Controlled Trial (RCT)
title_short Comparison of Continuous Epidural Infusion of Bupivacaine and Fentanyl Versus Patient Controlled Analgesia Techniques for Labor Analgesia: A Randomized Controlled Trial (RCT)
title_sort comparison of continuous epidural infusion of bupivacaine and fentanyl versus patient controlled analgesia techniques for labor analgesia: a randomized controlled trial (rct)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048688/
https://www.ncbi.nlm.nih.gov/pubmed/32175264
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