Cargando…
Comparison of Continuous Epidural Infusion of Bupivacaine and Fentanyl Versus Patient Controlled Analgesia Techniques for Labor Analgesia: A Randomized Controlled Trial (RCT)
BACKGROUND: To diminish labor pain, several techniques have been used in developed countries. In the current randomized controlled trial, the use of epidural analgesia via PCEA pump with and without background infusion of analgesic was studied. METHODS: In this double-blinded controlled trial, 60 wo...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Avicenna Research Institute
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048688/ https://www.ncbi.nlm.nih.gov/pubmed/32175264 |
_version_ | 1783502310825000960 |
---|---|
author | Khaneshi, Raha Rasooli, Sousan Moslemi, Farnaz Fakour, Sanam |
author_facet | Khaneshi, Raha Rasooli, Sousan Moslemi, Farnaz Fakour, Sanam |
author_sort | Khaneshi, Raha |
collection | PubMed |
description | BACKGROUND: To diminish labor pain, several techniques have been used in developed countries. In the current randomized controlled trial, the use of epidural analgesia via PCEA pump with and without background infusion of analgesic was studied. METHODS: In this double-blinded controlled trial, 60 women were enrolled and randomly assigned to study groups for receiving epidural analgesia during labor. All patients received initial bullous dose including 125 mg bupivacaine and 3 mg/ml fentanyl, and the first group patient (CI) received background infusion of 8 ml/hr and the second group (PCEA) received 10 ml bullous dose of 125 mg bupivacaine combined with 100 mcg fentanyl (2 ml) via epidural catheter. The Visual Analogue Scale (VAS) of 0–10 was measured 20 min after drug injection. The chi-square and student T-test were used for comparing variables between groups, and 0.05 was considered as the level of significance. RESULTS: There was no significant difference in terms of demographic variables. Mean duration of the second stage of labor was significantly lower in patients received continuous infusion (CI) (p<0.0001). However, the total administered fentanyl dose was significantly higher in patients who underwent PCEA (p<0.0001). Besides, the CI group had a significantly lower rate of patient-controlled injection compared to PCEA patients (p<0.0001). However, there was no significant difference between patients’ satisfaction and VAS in study groups. CONCLUSION: Epidural analgesia using PCEA combined with continuous infusion did not provide higher analgesia or patients’ satisfaction compared to PCEA alone; however, it led to a decreased rate of drug injection and total administered dosage. |
format | Online Article Text |
id | pubmed-7048688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Avicenna Research Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-70486882020-03-13 Comparison of Continuous Epidural Infusion of Bupivacaine and Fentanyl Versus Patient Controlled Analgesia Techniques for Labor Analgesia: A Randomized Controlled Trial (RCT) Khaneshi, Raha Rasooli, Sousan Moslemi, Farnaz Fakour, Sanam J Reprod Infertil Original Article BACKGROUND: To diminish labor pain, several techniques have been used in developed countries. In the current randomized controlled trial, the use of epidural analgesia via PCEA pump with and without background infusion of analgesic was studied. METHODS: In this double-blinded controlled trial, 60 women were enrolled and randomly assigned to study groups for receiving epidural analgesia during labor. All patients received initial bullous dose including 125 mg bupivacaine and 3 mg/ml fentanyl, and the first group patient (CI) received background infusion of 8 ml/hr and the second group (PCEA) received 10 ml bullous dose of 125 mg bupivacaine combined with 100 mcg fentanyl (2 ml) via epidural catheter. The Visual Analogue Scale (VAS) of 0–10 was measured 20 min after drug injection. The chi-square and student T-test were used for comparing variables between groups, and 0.05 was considered as the level of significance. RESULTS: There was no significant difference in terms of demographic variables. Mean duration of the second stage of labor was significantly lower in patients received continuous infusion (CI) (p<0.0001). However, the total administered fentanyl dose was significantly higher in patients who underwent PCEA (p<0.0001). Besides, the CI group had a significantly lower rate of patient-controlled injection compared to PCEA patients (p<0.0001). However, there was no significant difference between patients’ satisfaction and VAS in study groups. CONCLUSION: Epidural analgesia using PCEA combined with continuous infusion did not provide higher analgesia or patients’ satisfaction compared to PCEA alone; however, it led to a decreased rate of drug injection and total administered dosage. Avicenna Research Institute 2020 /pmc/articles/PMC7048688/ /pubmed/32175264 Text en Copyright© 2020, Avicenna Research Institute. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Khaneshi, Raha Rasooli, Sousan Moslemi, Farnaz Fakour, Sanam Comparison of Continuous Epidural Infusion of Bupivacaine and Fentanyl Versus Patient Controlled Analgesia Techniques for Labor Analgesia: A Randomized Controlled Trial (RCT) |
title | Comparison of Continuous Epidural Infusion of Bupivacaine and Fentanyl Versus Patient Controlled Analgesia Techniques for Labor Analgesia: A Randomized Controlled Trial (RCT) |
title_full | Comparison of Continuous Epidural Infusion of Bupivacaine and Fentanyl Versus Patient Controlled Analgesia Techniques for Labor Analgesia: A Randomized Controlled Trial (RCT) |
title_fullStr | Comparison of Continuous Epidural Infusion of Bupivacaine and Fentanyl Versus Patient Controlled Analgesia Techniques for Labor Analgesia: A Randomized Controlled Trial (RCT) |
title_full_unstemmed | Comparison of Continuous Epidural Infusion of Bupivacaine and Fentanyl Versus Patient Controlled Analgesia Techniques for Labor Analgesia: A Randomized Controlled Trial (RCT) |
title_short | Comparison of Continuous Epidural Infusion of Bupivacaine and Fentanyl Versus Patient Controlled Analgesia Techniques for Labor Analgesia: A Randomized Controlled Trial (RCT) |
title_sort | comparison of continuous epidural infusion of bupivacaine and fentanyl versus patient controlled analgesia techniques for labor analgesia: a randomized controlled trial (rct) |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048688/ https://www.ncbi.nlm.nih.gov/pubmed/32175264 |
work_keys_str_mv | AT khaneshiraha comparisonofcontinuousepiduralinfusionofbupivacaineandfentanylversuspatientcontrolledanalgesiatechniquesforlaboranalgesiaarandomizedcontrolledtrialrct AT rasoolisousan comparisonofcontinuousepiduralinfusionofbupivacaineandfentanylversuspatientcontrolledanalgesiatechniquesforlaboranalgesiaarandomizedcontrolledtrialrct AT moslemifarnaz comparisonofcontinuousepiduralinfusionofbupivacaineandfentanylversuspatientcontrolledanalgesiatechniquesforlaboranalgesiaarandomizedcontrolledtrialrct AT fakoursanam comparisonofcontinuousepiduralinfusionofbupivacaineandfentanylversuspatientcontrolledanalgesiatechniquesforlaboranalgesiaarandomizedcontrolledtrialrct |