Anxiolytic Drug FGIN-1-27 Ameliorates Autoimmunity by Metabolic Reprogramming of Pathogenic Th17 Cells

Th17 cells are critical drivers of autoimmune diseases and immunopathology. There is an unmet need to develop therapies targeting pathogenic Th17 cells for the treatment of autoimmune disorders. Here, we report that anxiolytic FGIN-1-27 inhibits differentiation and pathogenicity of Th17 cells in vit...

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Detalles Bibliográficos
Autores principales: Singh, Anju, Dashnyam, Myagmarjav, Chim, Bryan, Escobar, Thelma M., Dulcey, Andrés E., Hu, Xin, Wilson, Kelli M., Koganti, Prasanthi P., Spinner, Camille A., Xu, Xin, Jadhav, Ajit, Southall, Noel, Marugan, Juan, Selvaraj, Vimal, Lazarevic, Vanja, Muljo, Stefan A., Ferrer, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048748/
https://www.ncbi.nlm.nih.gov/pubmed/32111885
http://dx.doi.org/10.1038/s41598-020-60610-5

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