Single-molecule imaging of PI(4,5)P(2) and PTEN in vitro reveals a positive feedback mechanism for PTEN membrane binding

PTEN, a 3-phosphatase of phosphoinositide, regulates asymmetric PI(3,4,5)P(3) signaling for the anterior-posterior polarization and migration of motile cells. PTEN acts through posterior localization on the plasma membrane, but the mechanism for this accumulation is poorly understood. Here we develo...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoshioka, Daisuke, Fukushima, Seiya, Koteishi, Hiroyasu, Okuno, Daichi, Ide, Toru, Matsuoka, Satomi, Ueda, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048775/
https://www.ncbi.nlm.nih.gov/pubmed/32111929
http://dx.doi.org/10.1038/s42003-020-0818-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048775/
https://www.ncbi.nlm.nih.gov/pubmed/32111929
http://dx.doi.org/10.1038/s42003-020-0818-3

Ejemplares similares