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Single-molecule imaging of PI(4,5)P(2) and PTEN in vitro reveals a positive feedback mechanism for PTEN membrane binding
PTEN, a 3-phosphatase of phosphoinositide, regulates asymmetric PI(3,4,5)P(3) signaling for the anterior-posterior polarization and migration of motile cells. PTEN acts through posterior localization on the plasma membrane, but the mechanism for this accumulation is poorly understood. Here we develo...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048775/ https://www.ncbi.nlm.nih.gov/pubmed/32111929 http://dx.doi.org/10.1038/s42003-020-0818-3 |