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Effect direction meta-analysis of GWAS identifies extreme, prevalent and shared pleiotropy in a large mammal

In genome-wide association studies (GWAS), variants showing consistent effect directions across populations are considered as true discoveries. We model this information in an Effect Direction MEta-analysis (EDME) to quantify pleiotropy using GWAS of 34 Cholesky-decorrelated traits in 44,000+ cattle...

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Detalles Bibliográficos
Autores principales:	Xiang, Ruidong, van den Berg, Irene, MacLeod, Iona M., Daetwyler, Hans D., Goddard, Michael E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048789/ https://www.ncbi.nlm.nih.gov/pubmed/32111961 http://dx.doi.org/10.1038/s42003-020-0823-6

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