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Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a fatal and incurable form of interstitial lung disease in which persistent injury results in scar tissue formation. As fibrosis thickens, the lung tissue loses the ability to facilitate gas exchange and provide cells with needed oxygen. Currently, IPF has few...

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Autores principales: Dinh, Phuong-Uyen C., Paudel, Dipti, Brochu, Hayden, Popowski, Kristen D., Gracieux, M. Cyndell, Cores, Jhon, Huang, Ke, Hensley, M. Taylor, Harrell, Erin, Vandergriff, Adam C., George, Arianna K., Barrio, Raina T., Hu, Shiqi, Allen, Tyler A., Blackburn, Kevin, Caranasos, Thomas G., Peng, Xinxia, Schnabel, Lauren V., Adler, Kenneth B., Lobo, Leonard J., Goshe, Michael B., Cheng, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048814/
https://www.ncbi.nlm.nih.gov/pubmed/32111836
http://dx.doi.org/10.1038/s41467-020-14344-7
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author Dinh, Phuong-Uyen C.
Paudel, Dipti
Brochu, Hayden
Popowski, Kristen D.
Gracieux, M. Cyndell
Cores, Jhon
Huang, Ke
Hensley, M. Taylor
Harrell, Erin
Vandergriff, Adam C.
George, Arianna K.
Barrio, Raina T.
Hu, Shiqi
Allen, Tyler A.
Blackburn, Kevin
Caranasos, Thomas G.
Peng, Xinxia
Schnabel, Lauren V.
Adler, Kenneth B.
Lobo, Leonard J.
Goshe, Michael B.
Cheng, Ke
author_facet Dinh, Phuong-Uyen C.
Paudel, Dipti
Brochu, Hayden
Popowski, Kristen D.
Gracieux, M. Cyndell
Cores, Jhon
Huang, Ke
Hensley, M. Taylor
Harrell, Erin
Vandergriff, Adam C.
George, Arianna K.
Barrio, Raina T.
Hu, Shiqi
Allen, Tyler A.
Blackburn, Kevin
Caranasos, Thomas G.
Peng, Xinxia
Schnabel, Lauren V.
Adler, Kenneth B.
Lobo, Leonard J.
Goshe, Michael B.
Cheng, Ke
author_sort Dinh, Phuong-Uyen C.
collection PubMed
description Idiopathic pulmonary fibrosis (IPF) is a fatal and incurable form of interstitial lung disease in which persistent injury results in scar tissue formation. As fibrosis thickens, the lung tissue loses the ability to facilitate gas exchange and provide cells with needed oxygen. Currently, IPF has few treatment options and no effective therapies, aside from lung transplant. Here we present a series of studies utilizing lung spheroid cell-secretome (LSC-Sec) and exosomes (LSC-Exo) by inhalation to treat different models of lung injury and fibrosis. Analysis reveals that LSC-Sec and LSC-Exo treatments could attenuate and resolve bleomycin- and silica-induced fibrosis by reestablishing normal alveolar structure and decreasing both collagen accumulation and myofibroblast proliferation. Additionally, LSC-Sec and LSC-Exo exhibit superior therapeutic benefits than their counterparts derived from mesenchymal stem cells in some measures. We showed that an inhalation treatment of secretome and exosome exhibited therapeutic potential for lung regeneration in two experimental models of pulmonary fibrosis.
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spelling pubmed-70488142020-03-02 Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis Dinh, Phuong-Uyen C. Paudel, Dipti Brochu, Hayden Popowski, Kristen D. Gracieux, M. Cyndell Cores, Jhon Huang, Ke Hensley, M. Taylor Harrell, Erin Vandergriff, Adam C. George, Arianna K. Barrio, Raina T. Hu, Shiqi Allen, Tyler A. Blackburn, Kevin Caranasos, Thomas G. Peng, Xinxia Schnabel, Lauren V. Adler, Kenneth B. Lobo, Leonard J. Goshe, Michael B. Cheng, Ke Nat Commun Article Idiopathic pulmonary fibrosis (IPF) is a fatal and incurable form of interstitial lung disease in which persistent injury results in scar tissue formation. As fibrosis thickens, the lung tissue loses the ability to facilitate gas exchange and provide cells with needed oxygen. Currently, IPF has few treatment options and no effective therapies, aside from lung transplant. Here we present a series of studies utilizing lung spheroid cell-secretome (LSC-Sec) and exosomes (LSC-Exo) by inhalation to treat different models of lung injury and fibrosis. Analysis reveals that LSC-Sec and LSC-Exo treatments could attenuate and resolve bleomycin- and silica-induced fibrosis by reestablishing normal alveolar structure and decreasing both collagen accumulation and myofibroblast proliferation. Additionally, LSC-Sec and LSC-Exo exhibit superior therapeutic benefits than their counterparts derived from mesenchymal stem cells in some measures. We showed that an inhalation treatment of secretome and exosome exhibited therapeutic potential for lung regeneration in two experimental models of pulmonary fibrosis. Nature Publishing Group UK 2020-02-28 /pmc/articles/PMC7048814/ /pubmed/32111836 http://dx.doi.org/10.1038/s41467-020-14344-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Dinh, Phuong-Uyen C.
Paudel, Dipti
Brochu, Hayden
Popowski, Kristen D.
Gracieux, M. Cyndell
Cores, Jhon
Huang, Ke
Hensley, M. Taylor
Harrell, Erin
Vandergriff, Adam C.
George, Arianna K.
Barrio, Raina T.
Hu, Shiqi
Allen, Tyler A.
Blackburn, Kevin
Caranasos, Thomas G.
Peng, Xinxia
Schnabel, Lauren V.
Adler, Kenneth B.
Lobo, Leonard J.
Goshe, Michael B.
Cheng, Ke
Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
title Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
title_full Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
title_fullStr Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
title_full_unstemmed Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
title_short Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
title_sort inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048814/
https://www.ncbi.nlm.nih.gov/pubmed/32111836
http://dx.doi.org/10.1038/s41467-020-14344-7
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