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Structure of the processive human Pol δ holoenzyme

In eukaryotes, DNA polymerase δ (Pol δ) bound to the proliferating cell nuclear antigen (PCNA) replicates the lagging strand and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki fragments for their ligation. We present the high-resolution cryo-EM structure of the human processive Po...

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Detalles Bibliográficos
Autores principales:	Lancey, Claudia, Tehseen, Muhammad, Raducanu, Vlad-Stefan, Rashid, Fahad, Merino, Nekane, Ragan, Timothy J., Savva, Christos G., Zaher, Manal S., Shirbini, Afnan, Blanco, Francisco J., Hamdan, Samir M., De Biasio, Alfredo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048817/ https://www.ncbi.nlm.nih.gov/pubmed/32111820 http://dx.doi.org/10.1038/s41467-020-14898-6

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