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Characterization of the Airflow within an Average Geometry of the Healthy Human Nasal Cavity

This study’s objective was the generation of a standardized geometry of the healthy nasal cavity. An average geometry of the healthy nasal cavity was generated using a statistical shape model based on 25 symptom-free subjects. Airflow within the average geometry and these geometries was calculated u...

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Autores principales: Brüning, Jan, Hildebrandt, Thomas, Heppt, Werner, Schmidt, Nora, Lamecker, Hans, Szengel, Angelika, Amiridze, Natalja, Ramm, Heiko, Bindernagel, Matthias, Zachow, Stefan, Goubergrits, Leonid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048824/
https://www.ncbi.nlm.nih.gov/pubmed/32111935
http://dx.doi.org/10.1038/s41598-020-60755-3
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author Brüning, Jan
Hildebrandt, Thomas
Heppt, Werner
Schmidt, Nora
Lamecker, Hans
Szengel, Angelika
Amiridze, Natalja
Ramm, Heiko
Bindernagel, Matthias
Zachow, Stefan
Goubergrits, Leonid
author_facet Brüning, Jan
Hildebrandt, Thomas
Heppt, Werner
Schmidt, Nora
Lamecker, Hans
Szengel, Angelika
Amiridze, Natalja
Ramm, Heiko
Bindernagel, Matthias
Zachow, Stefan
Goubergrits, Leonid
author_sort Brüning, Jan
collection PubMed
description This study’s objective was the generation of a standardized geometry of the healthy nasal cavity. An average geometry of the healthy nasal cavity was generated using a statistical shape model based on 25 symptom-free subjects. Airflow within the average geometry and these geometries was calculated using fluid simulations. Integral measures of the nasal resistance, wall shear stresses (WSS) and velocities were calculated as well as cross-sectional areas (CSA). Furthermore, individual WSS and static pressure distributions were mapped onto the average geometry. The average geometry featured an overall more regular shape that resulted in less resistance, reduced WSS and velocities compared to the median of the 25 geometries. Spatial distributions of WSS and pressure of the average geometry agreed well compared to the average distributions of all individual geometries. The minimal CSA of the average geometry was larger than the median of all individual geometries (83.4 vs. 74.7 mm²). The airflow observed within the average geometry of the healthy nasal cavity did not equal the average airflow of the individual geometries. While differences observed for integral measures were notable, the calculated values for the average geometry lay within the distributions of the individual parameters. Spatially resolved parameters differed less prominently.
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spelling pubmed-70488242020-03-06 Characterization of the Airflow within an Average Geometry of the Healthy Human Nasal Cavity Brüning, Jan Hildebrandt, Thomas Heppt, Werner Schmidt, Nora Lamecker, Hans Szengel, Angelika Amiridze, Natalja Ramm, Heiko Bindernagel, Matthias Zachow, Stefan Goubergrits, Leonid Sci Rep Article This study’s objective was the generation of a standardized geometry of the healthy nasal cavity. An average geometry of the healthy nasal cavity was generated using a statistical shape model based on 25 symptom-free subjects. Airflow within the average geometry and these geometries was calculated using fluid simulations. Integral measures of the nasal resistance, wall shear stresses (WSS) and velocities were calculated as well as cross-sectional areas (CSA). Furthermore, individual WSS and static pressure distributions were mapped onto the average geometry. The average geometry featured an overall more regular shape that resulted in less resistance, reduced WSS and velocities compared to the median of the 25 geometries. Spatial distributions of WSS and pressure of the average geometry agreed well compared to the average distributions of all individual geometries. The minimal CSA of the average geometry was larger than the median of all individual geometries (83.4 vs. 74.7 mm²). The airflow observed within the average geometry of the healthy nasal cavity did not equal the average airflow of the individual geometries. While differences observed for integral measures were notable, the calculated values for the average geometry lay within the distributions of the individual parameters. Spatially resolved parameters differed less prominently. Nature Publishing Group UK 2020-02-28 /pmc/articles/PMC7048824/ /pubmed/32111935 http://dx.doi.org/10.1038/s41598-020-60755-3 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Brüning, Jan
Hildebrandt, Thomas
Heppt, Werner
Schmidt, Nora
Lamecker, Hans
Szengel, Angelika
Amiridze, Natalja
Ramm, Heiko
Bindernagel, Matthias
Zachow, Stefan
Goubergrits, Leonid
Characterization of the Airflow within an Average Geometry of the Healthy Human Nasal Cavity
title Characterization of the Airflow within an Average Geometry of the Healthy Human Nasal Cavity
title_full Characterization of the Airflow within an Average Geometry of the Healthy Human Nasal Cavity
title_fullStr Characterization of the Airflow within an Average Geometry of the Healthy Human Nasal Cavity
title_full_unstemmed Characterization of the Airflow within an Average Geometry of the Healthy Human Nasal Cavity
title_short Characterization of the Airflow within an Average Geometry of the Healthy Human Nasal Cavity
title_sort characterization of the airflow within an average geometry of the healthy human nasal cavity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048824/
https://www.ncbi.nlm.nih.gov/pubmed/32111935
http://dx.doi.org/10.1038/s41598-020-60755-3
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