Plaque Rupture-Induced Myocardial Infarction and Mechanical Circulatory Support in Alpha-Gal Allergy

Alpha-gal (AG) allergy is an IgE-mediated allergic reaction to galactose-alpha-1,3-galactose found in mammalian meat. Heparin, being derived from porcine intestinal tissue, may have a degree of cross-reactivity with AG antigen and thus place patients at risk for allergic and even anaphylactic reacti...

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Autores principales: Radwan, Sohab S., Gill, Gauravpal, Ghazzal, Amre, Malik, Awais, Barnett, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048905/
https://www.ncbi.nlm.nih.gov/pubmed/32128263
http://dx.doi.org/10.1155/2020/5282843
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author Radwan, Sohab S.
Gill, Gauravpal
Ghazzal, Amre
Malik, Awais
Barnett, Christopher
author_facet Radwan, Sohab S.
Gill, Gauravpal
Ghazzal, Amre
Malik, Awais
Barnett, Christopher
author_sort Radwan, Sohab S.
collection PubMed
description Alpha-gal (AG) allergy is an IgE-mediated allergic reaction to galactose-alpha-1,3-galactose found in mammalian meat. Heparin, being derived from porcine intestinal tissue, may have a degree of cross-reactivity with AG antigen and thus place patients at risk for allergic and even anaphylactic reactions. This is especially important in patients with myocardial infarction (MI) and mechanical circulatory support, such as a left ventricular assist device (LVAD), since anticoagulation is immediately required. Therefore, individualized assessment and preoperative planning is needed regarding the use of heparin vs. nonheparinoid products in such a population.
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spelling pubmed-70489052020-03-03 Plaque Rupture-Induced Myocardial Infarction and Mechanical Circulatory Support in Alpha-Gal Allergy Radwan, Sohab S. Gill, Gauravpal Ghazzal, Amre Malik, Awais Barnett, Christopher Case Rep Cardiol Case Report Alpha-gal (AG) allergy is an IgE-mediated allergic reaction to galactose-alpha-1,3-galactose found in mammalian meat. Heparin, being derived from porcine intestinal tissue, may have a degree of cross-reactivity with AG antigen and thus place patients at risk for allergic and even anaphylactic reactions. This is especially important in patients with myocardial infarction (MI) and mechanical circulatory support, such as a left ventricular assist device (LVAD), since anticoagulation is immediately required. Therefore, individualized assessment and preoperative planning is needed regarding the use of heparin vs. nonheparinoid products in such a population. Hindawi 2020-02-17 /pmc/articles/PMC7048905/ /pubmed/32128263 http://dx.doi.org/10.1155/2020/5282843 Text en Copyright © 2020 Sohab S. Radwan et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Radwan, Sohab S.
Gill, Gauravpal
Ghazzal, Amre
Malik, Awais
Barnett, Christopher
Plaque Rupture-Induced Myocardial Infarction and Mechanical Circulatory Support in Alpha-Gal Allergy
title Plaque Rupture-Induced Myocardial Infarction and Mechanical Circulatory Support in Alpha-Gal Allergy
title_full Plaque Rupture-Induced Myocardial Infarction and Mechanical Circulatory Support in Alpha-Gal Allergy
title_fullStr Plaque Rupture-Induced Myocardial Infarction and Mechanical Circulatory Support in Alpha-Gal Allergy
title_full_unstemmed Plaque Rupture-Induced Myocardial Infarction and Mechanical Circulatory Support in Alpha-Gal Allergy
title_short Plaque Rupture-Induced Myocardial Infarction and Mechanical Circulatory Support in Alpha-Gal Allergy
title_sort plaque rupture-induced myocardial infarction and mechanical circulatory support in alpha-gal allergy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048905/
https://www.ncbi.nlm.nih.gov/pubmed/32128263
http://dx.doi.org/10.1155/2020/5282843
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