Metalloprotoporphyrin Inhibition of HCV NS3-4A Protease: Structure–Activity Relationships

BACKGROUND: Antiviral actions of tetrapyrroles have been described in a number of systems. Our goal was to evaluate antagonism of the HCV NS3-4A protease by a variety of common porphyrins and characterize structure–activity relationships that may be useful for future drug design of HCV and related F...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Katherine, Zhu, Zhaowen, Mathahs, Meleah M, Tran, Huy, Bommer, Jerry, Testa, Charles A, Schmidt, Warren N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048954/
https://www.ncbi.nlm.nih.gov/pubmed/32158194
http://dx.doi.org/10.2147/DDDT.S201089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048954/
https://www.ncbi.nlm.nih.gov/pubmed/32158194
http://dx.doi.org/10.2147/DDDT.S201089

Ejemplares similares