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Tumor Mutational Burden From Tumor-Only Sequencing Compared With Germline Subtraction From Paired Tumor and Normal Specimens

IMPORTANCE: Tumor mutation burden (TMB) is an emerging factor associated with survival with immunotherapy. When tumor-normal pairs are available, TMB is determined by calculating the difference between somatic and germline sequences. In the case of commonly used tumor-only sequencing, additional ste...

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Detalles Bibliográficos
Autores principales:	Parikh, Kaushal, Huether, Robert, White, Kevin, Hoskinson, Derick, Beaubier, Nike, Dong, Haidong, Adjei, Alex A., Mansfield, Aaron S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Medical Association 2020
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049088/ https://www.ncbi.nlm.nih.gov/pubmed/32108894 http://dx.doi.org/10.1001/jamanetworkopen.2020.0202

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