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Three-dimensional surface imaging in breast cancer: a new tool for clinical studies?
BACKGROUND: Three-dimensional Surface Imaging (3DSI) is a well-established method to objectively monitor morphological changes in the female breast in the field of plastic surgery. In contrast, in radiation oncology we are still missing effective tools, which can objectively and reproducibly assess...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049187/ https://www.ncbi.nlm.nih.gov/pubmed/32111228 http://dx.doi.org/10.1186/s13014-020-01499-2 |
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author | Koban, Konstantin Christoph Etzel, Lucas Li, Zhouxiao Pazos, Montserrat Schönecker, Stephan Belka, Claus Giunta, Riccardo Enzo Schenck, Thilo Ludwig Corradini, Stefanie |
author_facet | Koban, Konstantin Christoph Etzel, Lucas Li, Zhouxiao Pazos, Montserrat Schönecker, Stephan Belka, Claus Giunta, Riccardo Enzo Schenck, Thilo Ludwig Corradini, Stefanie |
author_sort | Koban, Konstantin Christoph |
collection | PubMed |
description | BACKGROUND: Three-dimensional Surface Imaging (3DSI) is a well-established method to objectively monitor morphological changes in the female breast in the field of plastic surgery. In contrast, in radiation oncology we are still missing effective tools, which can objectively and reproducibly assess and document adverse events in breast cancer radiotherapy within the framework of clinical studies. The aim of the present study was to apply structured-light technology as a non-invasive and objective approach for the documentation of cosmetic outcome and early effects of breast radiotherapy as a proof of principle. METHODS: Weekly 3DSI images of patients receiving either conventionally fractionated radiation treatment (CF-RT) or hypofractionated radiation treatment (HF-RT) were acquired during the radiotherapy treatment and clinical follow-up. The portable Artec Eva scanner (Artec 3D Inc., Luxembourg) recorded 3D surface images for the analysis of breast volumes and changes in skin appearance. Statistical analysis compared the impact of the two different fractionation regimens and the differences between the treated and the contralateral healthy breast. RESULTS: Overall, 38 patients and a total of 214 breast imaging sessions were analysed. Patients receiving CF-RT showed a significantly higher frequency of breast erythema compared to HF-RT (93.3% versus 34.8%, p = 0.003) during all observed imaging sessions. Moreover, we found a statistically significant (p < 0.05) volumetric increase of the treated breast of the entire cohort between baseline (379 ± 196 mL) and follow-up imaging at 3 months (437 ± 224 mL), as well as from week 3 of radiotherapy (391 ± 198 mL) to follow-up imaging. In both subgroups of patients undergoing either CF-RT or HF-RT, there was a statistically significant increase (p < 0.05) in breast volumes between baseline and 3 months follow-up. There were no statistically significant skin or volumetric changes of the untreated healthy breasts. CONCLUSIONS: This is the first study utilizing 3D structured-light technology as a non-invasive and objective approach for the documentation of patients receiving breast radiotherapy. 3DSI offers potential as a non-invasive tool to objectively and precisely monitor the female breast in a radiooncological setting, allowing clinicians to objectively distinguish outcomes of different therapy modalities. |
format | Online Article Text |
id | pubmed-7049187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-70491872020-03-05 Three-dimensional surface imaging in breast cancer: a new tool for clinical studies? Koban, Konstantin Christoph Etzel, Lucas Li, Zhouxiao Pazos, Montserrat Schönecker, Stephan Belka, Claus Giunta, Riccardo Enzo Schenck, Thilo Ludwig Corradini, Stefanie Radiat Oncol Research BACKGROUND: Three-dimensional Surface Imaging (3DSI) is a well-established method to objectively monitor morphological changes in the female breast in the field of plastic surgery. In contrast, in radiation oncology we are still missing effective tools, which can objectively and reproducibly assess and document adverse events in breast cancer radiotherapy within the framework of clinical studies. The aim of the present study was to apply structured-light technology as a non-invasive and objective approach for the documentation of cosmetic outcome and early effects of breast radiotherapy as a proof of principle. METHODS: Weekly 3DSI images of patients receiving either conventionally fractionated radiation treatment (CF-RT) or hypofractionated radiation treatment (HF-RT) were acquired during the radiotherapy treatment and clinical follow-up. The portable Artec Eva scanner (Artec 3D Inc., Luxembourg) recorded 3D surface images for the analysis of breast volumes and changes in skin appearance. Statistical analysis compared the impact of the two different fractionation regimens and the differences between the treated and the contralateral healthy breast. RESULTS: Overall, 38 patients and a total of 214 breast imaging sessions were analysed. Patients receiving CF-RT showed a significantly higher frequency of breast erythema compared to HF-RT (93.3% versus 34.8%, p = 0.003) during all observed imaging sessions. Moreover, we found a statistically significant (p < 0.05) volumetric increase of the treated breast of the entire cohort between baseline (379 ± 196 mL) and follow-up imaging at 3 months (437 ± 224 mL), as well as from week 3 of radiotherapy (391 ± 198 mL) to follow-up imaging. In both subgroups of patients undergoing either CF-RT or HF-RT, there was a statistically significant increase (p < 0.05) in breast volumes between baseline and 3 months follow-up. There were no statistically significant skin or volumetric changes of the untreated healthy breasts. CONCLUSIONS: This is the first study utilizing 3D structured-light technology as a non-invasive and objective approach for the documentation of patients receiving breast radiotherapy. 3DSI offers potential as a non-invasive tool to objectively and precisely monitor the female breast in a radiooncological setting, allowing clinicians to objectively distinguish outcomes of different therapy modalities. BioMed Central 2020-02-28 /pmc/articles/PMC7049187/ /pubmed/32111228 http://dx.doi.org/10.1186/s13014-020-01499-2 Text en © The Author(s) 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Koban, Konstantin Christoph Etzel, Lucas Li, Zhouxiao Pazos, Montserrat Schönecker, Stephan Belka, Claus Giunta, Riccardo Enzo Schenck, Thilo Ludwig Corradini, Stefanie Three-dimensional surface imaging in breast cancer: a new tool for clinical studies? |
title | Three-dimensional surface imaging in breast cancer: a new tool for clinical studies? |
title_full | Three-dimensional surface imaging in breast cancer: a new tool for clinical studies? |
title_fullStr | Three-dimensional surface imaging in breast cancer: a new tool for clinical studies? |
title_full_unstemmed | Three-dimensional surface imaging in breast cancer: a new tool for clinical studies? |
title_short | Three-dimensional surface imaging in breast cancer: a new tool for clinical studies? |
title_sort | three-dimensional surface imaging in breast cancer: a new tool for clinical studies? |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049187/ https://www.ncbi.nlm.nih.gov/pubmed/32111228 http://dx.doi.org/10.1186/s13014-020-01499-2 |
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