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Injections of concentrated bone marrow aspirate as treatment for Discogenic pain: a retrospective analysis
BACKGROUND: There are an overwhelming number of patients suffering from low back pain (LBP) resulting from disc pathology. Although several strategies are being developed pre-clinically, simple strategies to treat the large number of patients currently affected is still needed. One option is to use...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049206/ https://www.ncbi.nlm.nih.gov/pubmed/32111220 http://dx.doi.org/10.1186/s12891-020-3126-7 |
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author | Wolff, Michael Shillington, Jon Mark Rathbone, Christopher Piasecki, Shawn K. Barnes, Brian |
author_facet | Wolff, Michael Shillington, Jon Mark Rathbone, Christopher Piasecki, Shawn K. Barnes, Brian |
author_sort | Wolff, Michael |
collection | PubMed |
description | BACKGROUND: There are an overwhelming number of patients suffering from low back pain (LBP) resulting from disc pathology. Although several strategies are being developed pre-clinically, simple strategies to treat the large number of patients currently affected is still needed. One option is to use concentrated bone marrow aspirate (cBMA), which may be effective due to its intrinsic stem cells and growth factors. METHODS: Thirty-three patients who received intradiscal injections of cBMA to relieve LBP were followed up based on Numeric Rating Scale (NRS), Oswestry Low Back Pain Disability Index (ODI), and Short Form-36 Health Survey (SF-36) scores. Patients were also subdivided into those with a pre-injection NRS > 5 and pre-injection NRS ≤ 5. The proportion of patients demonstrating at least 50% improvement (and 95% confidence intervals) from baseline at five follow-up visits for each outcome was evaluated. RESULTS: At least 50% improvement in NRS was observed for 13.8, 45.8, 41.1, 23.5, and 38.9% of patients across five follow-up visits, out to 1 year. When stratified by high (> 5) versus low (≤ 5) baseline NRS scores, the values were 14.3, 45.5, 71.4, 22.2, and 44.4% among those with high baseline pain, and 13.3, 46.2, 20.0, 25.0, and 33.3% among those with low baseline pain. The 50% improvement rates across visits were 4.3, 28.6, 30.0, 22.2, and 30.8% for SF-36, and 4.2, 26.7, 36.4, 55.6, and 30.8% for ODI. CONCLUSIONS: Intradiscal cBMA injections may be effective to reduce pain and improve function. Patients with relatively higher initial pain may have potential for greatest improvement. |
format | Online Article Text |
id | pubmed-7049206 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-70492062020-03-05 Injections of concentrated bone marrow aspirate as treatment for Discogenic pain: a retrospective analysis Wolff, Michael Shillington, Jon Mark Rathbone, Christopher Piasecki, Shawn K. Barnes, Brian BMC Musculoskelet Disord Research Article BACKGROUND: There are an overwhelming number of patients suffering from low back pain (LBP) resulting from disc pathology. Although several strategies are being developed pre-clinically, simple strategies to treat the large number of patients currently affected is still needed. One option is to use concentrated bone marrow aspirate (cBMA), which may be effective due to its intrinsic stem cells and growth factors. METHODS: Thirty-three patients who received intradiscal injections of cBMA to relieve LBP were followed up based on Numeric Rating Scale (NRS), Oswestry Low Back Pain Disability Index (ODI), and Short Form-36 Health Survey (SF-36) scores. Patients were also subdivided into those with a pre-injection NRS > 5 and pre-injection NRS ≤ 5. The proportion of patients demonstrating at least 50% improvement (and 95% confidence intervals) from baseline at five follow-up visits for each outcome was evaluated. RESULTS: At least 50% improvement in NRS was observed for 13.8, 45.8, 41.1, 23.5, and 38.9% of patients across five follow-up visits, out to 1 year. When stratified by high (> 5) versus low (≤ 5) baseline NRS scores, the values were 14.3, 45.5, 71.4, 22.2, and 44.4% among those with high baseline pain, and 13.3, 46.2, 20.0, 25.0, and 33.3% among those with low baseline pain. The 50% improvement rates across visits were 4.3, 28.6, 30.0, 22.2, and 30.8% for SF-36, and 4.2, 26.7, 36.4, 55.6, and 30.8% for ODI. CONCLUSIONS: Intradiscal cBMA injections may be effective to reduce pain and improve function. Patients with relatively higher initial pain may have potential for greatest improvement. BioMed Central 2020-02-28 /pmc/articles/PMC7049206/ /pubmed/32111220 http://dx.doi.org/10.1186/s12891-020-3126-7 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Wolff, Michael Shillington, Jon Mark Rathbone, Christopher Piasecki, Shawn K. Barnes, Brian Injections of concentrated bone marrow aspirate as treatment for Discogenic pain: a retrospective analysis |
title | Injections of concentrated bone marrow aspirate as treatment for Discogenic pain: a retrospective analysis |
title_full | Injections of concentrated bone marrow aspirate as treatment for Discogenic pain: a retrospective analysis |
title_fullStr | Injections of concentrated bone marrow aspirate as treatment for Discogenic pain: a retrospective analysis |
title_full_unstemmed | Injections of concentrated bone marrow aspirate as treatment for Discogenic pain: a retrospective analysis |
title_short | Injections of concentrated bone marrow aspirate as treatment for Discogenic pain: a retrospective analysis |
title_sort | injections of concentrated bone marrow aspirate as treatment for discogenic pain: a retrospective analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049206/ https://www.ncbi.nlm.nih.gov/pubmed/32111220 http://dx.doi.org/10.1186/s12891-020-3126-7 |
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