The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors

BACKGROUND: Cinobufagin is the major bufadienolide of Bufonis venenum (Chansu), which has been traditionally used for the treatment of chronic pain especially cancer pain. The current study aimed to evaluate its antinociceptive effects in bone cancer pain and explore the underlying mechanisms. METHO...

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Detalles Bibliográficos
Autores principales: Apryani, Evhy, Ali, Usman, Wang, Zi-Ying, Wu, Hai-Yun, Mao, Xiao-Fang, Ahmad, Khalil Ali, Li, Xin-Yan, Wang, Yong-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049212/
https://www.ncbi.nlm.nih.gov/pubmed/32113469
http://dx.doi.org/10.1186/s12974-019-1616-z

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