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Metabolic Stability Assessment of New PARP Inhibitor Talazoparib Using Validated LC–MS/MS Methodology: In silico Metabolic Vulnerability and Toxicity Studies

BACKGROUND: Talazoparib (BMN673) is a new poly(ADP-ribose) polymerase inhibitor that has been FDA approved for patients suffering from metastatic breast cancer with germline BRCA mutations. METHOD AND RESULTS: In the current study, an accurate and efficient liquid chromatography-tandem mass spectrom...

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Detalles Bibliográficos
Autores principales:	Attwa, Mohamed W, Kadi, Adnan A, Abdelhameed, Ali S, Alhazmi, Hassan A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049284/ https://www.ncbi.nlm.nih.gov/pubmed/32158196 http://dx.doi.org/10.2147/DDDT.S239458

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