Cargando…
Serum protein electrophoresis pattern in patients living with HIV: frequency of possible abnormalities in Iranian patients
BACKGROUND AND OBJECTIVES: This prospective case-control study was conducted to evaluate abnormal serum protein electrophoresis (SPEP) patterns in patients living with human immunodeficiency virus (HIV) and its relation with disease severity markers and anti-retroviral treatment status. MATERIALS AN...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049319/ https://www.ncbi.nlm.nih.gov/pubmed/32148675 |
_version_ | 1783502416812965888 |
---|---|
author | Nozarian, Zohreh Mehrtash, Vahid Abdollahi, Alireza Aeinehsazi, Saloomeh Khorsand, Atieh Eftekhar-Javadi, Arezoo Safaei, Masoumeh Nili, Fatemeh |
author_facet | Nozarian, Zohreh Mehrtash, Vahid Abdollahi, Alireza Aeinehsazi, Saloomeh Khorsand, Atieh Eftekhar-Javadi, Arezoo Safaei, Masoumeh Nili, Fatemeh |
author_sort | Nozarian, Zohreh |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: This prospective case-control study was conducted to evaluate abnormal serum protein electrophoresis (SPEP) patterns in patients living with human immunodeficiency virus (HIV) and its relation with disease severity markers and anti-retroviral treatment status. MATERIALS AND METHODS: Thirty-seven HIV-positive patients and 24 healthy individuals were evaluated in the course of this study. The healthy HIV-negative individuals were selected as control group. Pregnant women, patients with malignancies, children, hepatitis B- and/or C-positive patients, those with a history of an autoimmune disease, or previous corticosteroid administration were excluded. SPEP—which detects serum levels of albumin, total protein, gammaglobulin—, CD4+ T-cell counts, viral load, and antiretroviral treatment status were assessed. Data were analyzed by SPSS™ software. RESULTS: Twelve patients (32 percent) demonstrated polyclonal gammopathy on SPEP, while only 1 (4 percent) healthy individual had the same pattern (P-value = 0.007). No statistically significant connection between SPEP patterns and antiretroviral treatment status was observed (P-value > 0.05). Interestingly no statistically significant relationship between CD4+ T-cell counts and polyclonal gammopathy was discerned. No statistically significant difference was observed between the two groups with regards to serum albumin and total protein levels. The serum albumin to total protein percentage, serum gamma globulin to total protein percentage, and serum albumin to globulin ratio was compared between the groups and a statistically significant difference was observed. CONCLUSION: Polyclonal gammopathy on SPEP is common among HIV-infected patients. Moreover, the SPEP patterns cannot be used as an indication of a patient’s negative or positive response to treatment. |
format | Online Article Text |
id | pubmed-7049319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-70493192020-03-06 Serum protein electrophoresis pattern in patients living with HIV: frequency of possible abnormalities in Iranian patients Nozarian, Zohreh Mehrtash, Vahid Abdollahi, Alireza Aeinehsazi, Saloomeh Khorsand, Atieh Eftekhar-Javadi, Arezoo Safaei, Masoumeh Nili, Fatemeh Iran J Microbiol Original Article BACKGROUND AND OBJECTIVES: This prospective case-control study was conducted to evaluate abnormal serum protein electrophoresis (SPEP) patterns in patients living with human immunodeficiency virus (HIV) and its relation with disease severity markers and anti-retroviral treatment status. MATERIALS AND METHODS: Thirty-seven HIV-positive patients and 24 healthy individuals were evaluated in the course of this study. The healthy HIV-negative individuals were selected as control group. Pregnant women, patients with malignancies, children, hepatitis B- and/or C-positive patients, those with a history of an autoimmune disease, or previous corticosteroid administration were excluded. SPEP—which detects serum levels of albumin, total protein, gammaglobulin—, CD4+ T-cell counts, viral load, and antiretroviral treatment status were assessed. Data were analyzed by SPSS™ software. RESULTS: Twelve patients (32 percent) demonstrated polyclonal gammopathy on SPEP, while only 1 (4 percent) healthy individual had the same pattern (P-value = 0.007). No statistically significant connection between SPEP patterns and antiretroviral treatment status was observed (P-value > 0.05). Interestingly no statistically significant relationship between CD4+ T-cell counts and polyclonal gammopathy was discerned. No statistically significant difference was observed between the two groups with regards to serum albumin and total protein levels. The serum albumin to total protein percentage, serum gamma globulin to total protein percentage, and serum albumin to globulin ratio was compared between the groups and a statistically significant difference was observed. CONCLUSION: Polyclonal gammopathy on SPEP is common among HIV-infected patients. Moreover, the SPEP patterns cannot be used as an indication of a patient’s negative or positive response to treatment. Tehran University of Medical Sciences 2019-10 /pmc/articles/PMC7049319/ /pubmed/32148675 Text en Copyright© 2019 Iranian Neuroscience Society http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Nozarian, Zohreh Mehrtash, Vahid Abdollahi, Alireza Aeinehsazi, Saloomeh Khorsand, Atieh Eftekhar-Javadi, Arezoo Safaei, Masoumeh Nili, Fatemeh Serum protein electrophoresis pattern in patients living with HIV: frequency of possible abnormalities in Iranian patients |
title | Serum protein electrophoresis pattern in patients living with HIV: frequency of possible abnormalities in Iranian patients |
title_full | Serum protein electrophoresis pattern in patients living with HIV: frequency of possible abnormalities in Iranian patients |
title_fullStr | Serum protein electrophoresis pattern in patients living with HIV: frequency of possible abnormalities in Iranian patients |
title_full_unstemmed | Serum protein electrophoresis pattern in patients living with HIV: frequency of possible abnormalities in Iranian patients |
title_short | Serum protein electrophoresis pattern in patients living with HIV: frequency of possible abnormalities in Iranian patients |
title_sort | serum protein electrophoresis pattern in patients living with hiv: frequency of possible abnormalities in iranian patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049319/ https://www.ncbi.nlm.nih.gov/pubmed/32148675 |
work_keys_str_mv | AT nozarianzohreh serumproteinelectrophoresispatterninpatientslivingwithhivfrequencyofpossibleabnormalitiesiniranianpatients AT mehrtashvahid serumproteinelectrophoresispatterninpatientslivingwithhivfrequencyofpossibleabnormalitiesiniranianpatients AT abdollahialireza serumproteinelectrophoresispatterninpatientslivingwithhivfrequencyofpossibleabnormalitiesiniranianpatients AT aeinehsazisaloomeh serumproteinelectrophoresispatterninpatientslivingwithhivfrequencyofpossibleabnormalitiesiniranianpatients AT khorsandatieh serumproteinelectrophoresispatterninpatientslivingwithhivfrequencyofpossibleabnormalitiesiniranianpatients AT eftekharjavadiarezoo serumproteinelectrophoresispatterninpatientslivingwithhivfrequencyofpossibleabnormalitiesiniranianpatients AT safaeimasoumeh serumproteinelectrophoresispatterninpatientslivingwithhivfrequencyofpossibleabnormalitiesiniranianpatients AT nilifatemeh serumproteinelectrophoresispatterninpatientslivingwithhivfrequencyofpossibleabnormalitiesiniranianpatients |