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Probiotic Lactobacillus plantarum IS 10506 supplementation increase SCFA of women with functional constipation

BACKGROUND AND OBJECTIVES: Gut microbiota influences our health via multiple mechanisms. Microbiota produced Short Chain Fatty Acid (SCFA) as an energy to maintain gut ecosystem and physiology. Dysbiosis is correlated with SCFA imbalance which in turn resulted in physiological abnormalities in the i...

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Autores principales: Kusumo, Pratiwi Dyah, Maulahela, Hasan, Utari, Amanda Pitarini, Surono, Ingrid S., Soebandrio, Amin, Abdullah, Murdani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049320/
https://www.ncbi.nlm.nih.gov/pubmed/32148669
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author Kusumo, Pratiwi Dyah
Maulahela, Hasan
Utari, Amanda Pitarini
Surono, Ingrid S.
Soebandrio, Amin
Abdullah, Murdani
author_facet Kusumo, Pratiwi Dyah
Maulahela, Hasan
Utari, Amanda Pitarini
Surono, Ingrid S.
Soebandrio, Amin
Abdullah, Murdani
author_sort Kusumo, Pratiwi Dyah
collection PubMed
description BACKGROUND AND OBJECTIVES: Gut microbiota influences our health via multiple mechanisms. Microbiota produced Short Chain Fatty Acid (SCFA) as an energy to maintain gut ecosystem and physiology. Dysbiosis is correlated with SCFA imbalance which in turn resulted in physiological abnormalities in the intestine, such as functional constipation. MATERIALS AND METHODS: Randomized Double-Blind Controlled Trial (RCT) was conducted on women with functional constipation (n=37) in the community of Jakarta and profile of SCFA was assessed by using GC-MS from the stool after 21 days supplementation of fermented milk (placebo and probiotic). RESULTS: Probiotic supplementation significantly influenced acetate titer (p=0,032) marginally significant for propionate and butyrate (p=0.063 and p=0.068, respectively) and the respondent with increasing SCFA’s metabolite are higher in probiotic group compared to the respondents in placebo group. Acetate is the highest SCFA titer found in faeces samples of women with functional constipation. CONCLUSION: Probiotic Lactobacillus plantarum IS 10506 supplementation influenced all the SCFA parameter (acetate, propionate and butyrate).
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spelling pubmed-70493202020-03-06 Probiotic Lactobacillus plantarum IS 10506 supplementation increase SCFA of women with functional constipation Kusumo, Pratiwi Dyah Maulahela, Hasan Utari, Amanda Pitarini Surono, Ingrid S. Soebandrio, Amin Abdullah, Murdani Iran J Microbiol Original Article BACKGROUND AND OBJECTIVES: Gut microbiota influences our health via multiple mechanisms. Microbiota produced Short Chain Fatty Acid (SCFA) as an energy to maintain gut ecosystem and physiology. Dysbiosis is correlated with SCFA imbalance which in turn resulted in physiological abnormalities in the intestine, such as functional constipation. MATERIALS AND METHODS: Randomized Double-Blind Controlled Trial (RCT) was conducted on women with functional constipation (n=37) in the community of Jakarta and profile of SCFA was assessed by using GC-MS from the stool after 21 days supplementation of fermented milk (placebo and probiotic). RESULTS: Probiotic supplementation significantly influenced acetate titer (p=0,032) marginally significant for propionate and butyrate (p=0.063 and p=0.068, respectively) and the respondent with increasing SCFA’s metabolite are higher in probiotic group compared to the respondents in placebo group. Acetate is the highest SCFA titer found in faeces samples of women with functional constipation. CONCLUSION: Probiotic Lactobacillus plantarum IS 10506 supplementation influenced all the SCFA parameter (acetate, propionate and butyrate). Tehran University of Medical Sciences 2019-10 /pmc/articles/PMC7049320/ /pubmed/32148669 Text en Copyright© 2019 Iranian Neuroscience Society http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kusumo, Pratiwi Dyah
Maulahela, Hasan
Utari, Amanda Pitarini
Surono, Ingrid S.
Soebandrio, Amin
Abdullah, Murdani
Probiotic Lactobacillus plantarum IS 10506 supplementation increase SCFA of women with functional constipation
title Probiotic Lactobacillus plantarum IS 10506 supplementation increase SCFA of women with functional constipation
title_full Probiotic Lactobacillus plantarum IS 10506 supplementation increase SCFA of women with functional constipation
title_fullStr Probiotic Lactobacillus plantarum IS 10506 supplementation increase SCFA of women with functional constipation
title_full_unstemmed Probiotic Lactobacillus plantarum IS 10506 supplementation increase SCFA of women with functional constipation
title_short Probiotic Lactobacillus plantarum IS 10506 supplementation increase SCFA of women with functional constipation
title_sort probiotic lactobacillus plantarum is 10506 supplementation increase scfa of women with functional constipation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049320/
https://www.ncbi.nlm.nih.gov/pubmed/32148669
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