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Probiotic Lactobacillus plantarum IS 10506 supplementation increase SCFA of women with functional constipation
BACKGROUND AND OBJECTIVES: Gut microbiota influences our health via multiple mechanisms. Microbiota produced Short Chain Fatty Acid (SCFA) as an energy to maintain gut ecosystem and physiology. Dysbiosis is correlated with SCFA imbalance which in turn resulted in physiological abnormalities in the i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049320/ https://www.ncbi.nlm.nih.gov/pubmed/32148669 |
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author | Kusumo, Pratiwi Dyah Maulahela, Hasan Utari, Amanda Pitarini Surono, Ingrid S. Soebandrio, Amin Abdullah, Murdani |
author_facet | Kusumo, Pratiwi Dyah Maulahela, Hasan Utari, Amanda Pitarini Surono, Ingrid S. Soebandrio, Amin Abdullah, Murdani |
author_sort | Kusumo, Pratiwi Dyah |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: Gut microbiota influences our health via multiple mechanisms. Microbiota produced Short Chain Fatty Acid (SCFA) as an energy to maintain gut ecosystem and physiology. Dysbiosis is correlated with SCFA imbalance which in turn resulted in physiological abnormalities in the intestine, such as functional constipation. MATERIALS AND METHODS: Randomized Double-Blind Controlled Trial (RCT) was conducted on women with functional constipation (n=37) in the community of Jakarta and profile of SCFA was assessed by using GC-MS from the stool after 21 days supplementation of fermented milk (placebo and probiotic). RESULTS: Probiotic supplementation significantly influenced acetate titer (p=0,032) marginally significant for propionate and butyrate (p=0.063 and p=0.068, respectively) and the respondent with increasing SCFA’s metabolite are higher in probiotic group compared to the respondents in placebo group. Acetate is the highest SCFA titer found in faeces samples of women with functional constipation. CONCLUSION: Probiotic Lactobacillus plantarum IS 10506 supplementation influenced all the SCFA parameter (acetate, propionate and butyrate). |
format | Online Article Text |
id | pubmed-7049320 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-70493202020-03-06 Probiotic Lactobacillus plantarum IS 10506 supplementation increase SCFA of women with functional constipation Kusumo, Pratiwi Dyah Maulahela, Hasan Utari, Amanda Pitarini Surono, Ingrid S. Soebandrio, Amin Abdullah, Murdani Iran J Microbiol Original Article BACKGROUND AND OBJECTIVES: Gut microbiota influences our health via multiple mechanisms. Microbiota produced Short Chain Fatty Acid (SCFA) as an energy to maintain gut ecosystem and physiology. Dysbiosis is correlated with SCFA imbalance which in turn resulted in physiological abnormalities in the intestine, such as functional constipation. MATERIALS AND METHODS: Randomized Double-Blind Controlled Trial (RCT) was conducted on women with functional constipation (n=37) in the community of Jakarta and profile of SCFA was assessed by using GC-MS from the stool after 21 days supplementation of fermented milk (placebo and probiotic). RESULTS: Probiotic supplementation significantly influenced acetate titer (p=0,032) marginally significant for propionate and butyrate (p=0.063 and p=0.068, respectively) and the respondent with increasing SCFA’s metabolite are higher in probiotic group compared to the respondents in placebo group. Acetate is the highest SCFA titer found in faeces samples of women with functional constipation. CONCLUSION: Probiotic Lactobacillus plantarum IS 10506 supplementation influenced all the SCFA parameter (acetate, propionate and butyrate). Tehran University of Medical Sciences 2019-10 /pmc/articles/PMC7049320/ /pubmed/32148669 Text en Copyright© 2019 Iranian Neuroscience Society http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kusumo, Pratiwi Dyah Maulahela, Hasan Utari, Amanda Pitarini Surono, Ingrid S. Soebandrio, Amin Abdullah, Murdani Probiotic Lactobacillus plantarum IS 10506 supplementation increase SCFA of women with functional constipation |
title | Probiotic Lactobacillus plantarum IS 10506 supplementation increase SCFA of women with functional constipation |
title_full | Probiotic Lactobacillus plantarum IS 10506 supplementation increase SCFA of women with functional constipation |
title_fullStr | Probiotic Lactobacillus plantarum IS 10506 supplementation increase SCFA of women with functional constipation |
title_full_unstemmed | Probiotic Lactobacillus plantarum IS 10506 supplementation increase SCFA of women with functional constipation |
title_short | Probiotic Lactobacillus plantarum IS 10506 supplementation increase SCFA of women with functional constipation |
title_sort | probiotic lactobacillus plantarum is 10506 supplementation increase scfa of women with functional constipation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049320/ https://www.ncbi.nlm.nih.gov/pubmed/32148669 |
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