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Adherence to Allergen Subcutaneous Immunotherapy is Increased by a Shortened Build-Up Phase: A Retrospective Study
Introduction. The poor long-term adherence is known to affect the efficacy of allergen immunotherapy (AIT). In the case of injection AIT (SCIT), one of the main determinants is the inconvenience for patients to undergo prolonged build-up phases. Thus, simplifying the time schedule of the induction p...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049433/ https://www.ncbi.nlm.nih.gov/pubmed/32149130 http://dx.doi.org/10.1155/2020/7328469 |
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author | Caruso, Cristiano Bramé, Barbara Bagnasco, Diego Cocconcelli, Alessia Ortolani, Valeria Pravettoni, Valerio Scarpa, Sergio Zisa, Giuliana Passalacqua, Giovanni Colantuono, Stefania |
author_facet | Caruso, Cristiano Bramé, Barbara Bagnasco, Diego Cocconcelli, Alessia Ortolani, Valeria Pravettoni, Valerio Scarpa, Sergio Zisa, Giuliana Passalacqua, Giovanni Colantuono, Stefania |
author_sort | Caruso, Cristiano |
collection | PubMed |
description | Introduction. The poor long-term adherence is known to affect the efficacy of allergen immunotherapy (AIT). In the case of injection AIT (SCIT), one of the main determinants is the inconvenience for patients to undergo prolonged build-up phases. Thus, simplifying the time schedule of the induction protocol could be effective in increasing the adherence to SCIT. METHODS: We backtracked the SCIT renewal orders, thanks to the cooperation of the manufacturing company, and we compared the long-term adherence of 152 patients, who were prescribed with an abbreviated build-up schedule (4 injections, allergoid) with that of 302 patients treated with the same product, but with the traditional build-up protocol (7 injections). RESULTS: According to the patient-named refills, those patients on the abbreviated build-up were significantly more compliant at the 2nd and 3rd year of treatment compared to the other group (p=0.0001). The drop-out rate after one year was also significantly lower between the two groups (p=0.0001). The drop-out rate after one year was also significantly lower between the two groups (p=0.0001). The drop-out rate after one year was also significantly lower between the two groups ( CONCLUSIONS: Abbreviating the build-up phase by reducing the number of injections significantly improves patients' adherence to SCIT. |
format | Online Article Text |
id | pubmed-7049433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-70494332020-03-08 Adherence to Allergen Subcutaneous Immunotherapy is Increased by a Shortened Build-Up Phase: A Retrospective Study Caruso, Cristiano Bramé, Barbara Bagnasco, Diego Cocconcelli, Alessia Ortolani, Valeria Pravettoni, Valerio Scarpa, Sergio Zisa, Giuliana Passalacqua, Giovanni Colantuono, Stefania Biomed Res Int Research Article Introduction. The poor long-term adherence is known to affect the efficacy of allergen immunotherapy (AIT). In the case of injection AIT (SCIT), one of the main determinants is the inconvenience for patients to undergo prolonged build-up phases. Thus, simplifying the time schedule of the induction protocol could be effective in increasing the adherence to SCIT. METHODS: We backtracked the SCIT renewal orders, thanks to the cooperation of the manufacturing company, and we compared the long-term adherence of 152 patients, who were prescribed with an abbreviated build-up schedule (4 injections, allergoid) with that of 302 patients treated with the same product, but with the traditional build-up protocol (7 injections). RESULTS: According to the patient-named refills, those patients on the abbreviated build-up were significantly more compliant at the 2nd and 3rd year of treatment compared to the other group (p=0.0001). The drop-out rate after one year was also significantly lower between the two groups (p=0.0001). The drop-out rate after one year was also significantly lower between the two groups (p=0.0001). The drop-out rate after one year was also significantly lower between the two groups ( CONCLUSIONS: Abbreviating the build-up phase by reducing the number of injections significantly improves patients' adherence to SCIT. Hindawi 2020-02-18 /pmc/articles/PMC7049433/ /pubmed/32149130 http://dx.doi.org/10.1155/2020/7328469 Text en Copyright © 2020 Cristiano Caruso et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Caruso, Cristiano Bramé, Barbara Bagnasco, Diego Cocconcelli, Alessia Ortolani, Valeria Pravettoni, Valerio Scarpa, Sergio Zisa, Giuliana Passalacqua, Giovanni Colantuono, Stefania Adherence to Allergen Subcutaneous Immunotherapy is Increased by a Shortened Build-Up Phase: A Retrospective Study |
title | Adherence to Allergen Subcutaneous Immunotherapy is Increased by a Shortened Build-Up Phase: A Retrospective Study |
title_full | Adherence to Allergen Subcutaneous Immunotherapy is Increased by a Shortened Build-Up Phase: A Retrospective Study |
title_fullStr | Adherence to Allergen Subcutaneous Immunotherapy is Increased by a Shortened Build-Up Phase: A Retrospective Study |
title_full_unstemmed | Adherence to Allergen Subcutaneous Immunotherapy is Increased by a Shortened Build-Up Phase: A Retrospective Study |
title_short | Adherence to Allergen Subcutaneous Immunotherapy is Increased by a Shortened Build-Up Phase: A Retrospective Study |
title_sort | adherence to allergen subcutaneous immunotherapy is increased by a shortened build-up phase: a retrospective study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049433/ https://www.ncbi.nlm.nih.gov/pubmed/32149130 http://dx.doi.org/10.1155/2020/7328469 |
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