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Brachial-Ankle Pulse Wave Velocity is Increased and Associated with Disease Activity in Patients with Takayasu Arteritis
Aim: Takayasu arteritis (TAK) is a rare inflammatory large-vessel vasculitis with increased cardiovascular morbidity and mortality. Brachial-ankle pulse wave velocity (ba-PWV) is a widely used measure of arterial stiffness and serves as an indicator of either cardiovascular risk or severity of vascu...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japan Atherosclerosis Society
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049473/ https://www.ncbi.nlm.nih.gov/pubmed/31270281 http://dx.doi.org/10.5551/jat.48447 |
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author | Wang, Zhiguang Dang, Aimin Lv, Naqiang |
author_facet | Wang, Zhiguang Dang, Aimin Lv, Naqiang |
author_sort | Wang, Zhiguang |
collection | PubMed |
description | Aim: Takayasu arteritis (TAK) is a rare inflammatory large-vessel vasculitis with increased cardiovascular morbidity and mortality. Brachial-ankle pulse wave velocity (ba-PWV) is a widely used measure of arterial stiffness and serves as an indicator of either cardiovascular risk or severity of vascular damage. However, the studies about the relationship between TAK and ba-PWV are limited. This study aimed to investigate the use of ba-PWV in the patients with TAK. Methods: Sixty-seven patients with TAK and 67 age and sex matched healthy controls were recruited. Patients with TAK were grouped according to disease activity. The routine hematological parameters and ba-PWV were summarized. Results: Ba-PWV was significantly higher in the patients with TAK than in the healthy controls (P < 0.001). Ba-PWV was significantly higher in the patients with active TAK than in the patients with inactive TAK (P = 0.04). Multiple liner regression analysis indicated that TAK (β = 363.97, P = 0.013), and mean arterial pressure (MAP) (β = 8.52, P = 0.012) were independently related to ba-PWV. Ba-PWV did not correlate with C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in overall patients with TAK (both P > 0.05). In patients with TAK without immunosuppressive therapy, ba-PWV significantly correlated with CRP (r = 0.419, P = 0.008) but not ESR (P > 0.05). Multiple logistic regression analysis indicated that ba-PWV was an independent predictor of active TAK in overall patients with TAK (OR = 1.003, 95% CI = 1.000–1.007; P = 0.040) and patients with TAK without immunosuppressive therapy (OR = 1.006, 95% CI = 1.001–1.012; P = 0.031). Conclusions: Being significantly increased in patients with TAK, ba-PWV is significantly associated with TAK disease activity, and it probably correlates with systematic inflammation. |
format | Online Article Text |
id | pubmed-7049473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Japan Atherosclerosis Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-70494732020-03-06 Brachial-Ankle Pulse Wave Velocity is Increased and Associated with Disease Activity in Patients with Takayasu Arteritis Wang, Zhiguang Dang, Aimin Lv, Naqiang J Atheroscler Thromb Original Article Aim: Takayasu arteritis (TAK) is a rare inflammatory large-vessel vasculitis with increased cardiovascular morbidity and mortality. Brachial-ankle pulse wave velocity (ba-PWV) is a widely used measure of arterial stiffness and serves as an indicator of either cardiovascular risk or severity of vascular damage. However, the studies about the relationship between TAK and ba-PWV are limited. This study aimed to investigate the use of ba-PWV in the patients with TAK. Methods: Sixty-seven patients with TAK and 67 age and sex matched healthy controls were recruited. Patients with TAK were grouped according to disease activity. The routine hematological parameters and ba-PWV were summarized. Results: Ba-PWV was significantly higher in the patients with TAK than in the healthy controls (P < 0.001). Ba-PWV was significantly higher in the patients with active TAK than in the patients with inactive TAK (P = 0.04). Multiple liner regression analysis indicated that TAK (β = 363.97, P = 0.013), and mean arterial pressure (MAP) (β = 8.52, P = 0.012) were independently related to ba-PWV. Ba-PWV did not correlate with C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in overall patients with TAK (both P > 0.05). In patients with TAK without immunosuppressive therapy, ba-PWV significantly correlated with CRP (r = 0.419, P = 0.008) but not ESR (P > 0.05). Multiple logistic regression analysis indicated that ba-PWV was an independent predictor of active TAK in overall patients with TAK (OR = 1.003, 95% CI = 1.000–1.007; P = 0.040) and patients with TAK without immunosuppressive therapy (OR = 1.006, 95% CI = 1.001–1.012; P = 0.031). Conclusions: Being significantly increased in patients with TAK, ba-PWV is significantly associated with TAK disease activity, and it probably correlates with systematic inflammation. Japan Atherosclerosis Society 2020-02-01 /pmc/articles/PMC7049473/ /pubmed/31270281 http://dx.doi.org/10.5551/jat.48447 Text en 2020 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Original Article Wang, Zhiguang Dang, Aimin Lv, Naqiang Brachial-Ankle Pulse Wave Velocity is Increased and Associated with Disease Activity in Patients with Takayasu Arteritis |
title | Brachial-Ankle Pulse Wave Velocity is Increased and Associated with Disease Activity in Patients with Takayasu Arteritis |
title_full | Brachial-Ankle Pulse Wave Velocity is Increased and Associated with Disease Activity in Patients with Takayasu Arteritis |
title_fullStr | Brachial-Ankle Pulse Wave Velocity is Increased and Associated with Disease Activity in Patients with Takayasu Arteritis |
title_full_unstemmed | Brachial-Ankle Pulse Wave Velocity is Increased and Associated with Disease Activity in Patients with Takayasu Arteritis |
title_short | Brachial-Ankle Pulse Wave Velocity is Increased and Associated with Disease Activity in Patients with Takayasu Arteritis |
title_sort | brachial-ankle pulse wave velocity is increased and associated with disease activity in patients with takayasu arteritis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049473/ https://www.ncbi.nlm.nih.gov/pubmed/31270281 http://dx.doi.org/10.5551/jat.48447 |
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